使用前列腺素F2α、E2和催产素进行选择性引产对子宫收缩和舒张的影响。

Effect of elective induction of labor with prostaglandins F2alpha and E2 and oxytocin on uterine contraction and relaxation.

作者信息

Roux J F, Mofid M, Moss P L, Dmytrus K C

出版信息

Am J Obstet Gynecol. 1977 Apr 1;127(7):718-22. doi: 10.1016/0002-9378(77)90245-9.

Abstract

Prostaglandins F2alpha and E2 and oxytocin were used to induce labor in 101 patients at risks. The data show that the three drugs are efficient labor inducers. The success rate of induction is the highest in primiparous patients receiving oral prostaglandin E2. Uterine contractility patterns and base line are similar with all drugs. The relaxation phase of the uterine contraction is skewed consistently in each investigated labor. This suggests an unequal relaxation time for the uterine fibers. It is concluded that prostaglandins E2 and F2alpha and oxytocin are safe drugs for induction of labor if monitoring is used in order to avoid an overdose of the medication. The three drugs must be synergistic because of their identical action on the uterine muscle.

摘要

使用前列腺素F2α、E2和催产素对101名有风险的患者进行引产。数据表明，这三种药物都是有效的引产剂。口服前列腺素E2的初产妇引产成功率最高。所有药物的子宫收缩模式和基线相似。在每次调查的分娩中，子宫收缩的舒张期始终存在偏差。这表明子宫纤维的舒张时间不相等。得出的结论是，如果进行监测以避免药物过量，前列腺素E2、F2α和催产素是安全的引产药物。这三种药物对子宫肌肉的作用相同，因此必定具有协同作用。