糖皮质激素可增加肾刷状缘膜囊泡中的钠氢交换，并降低钠梯度依赖性磷酸盐摄取系统。
Glucocorticoids increase the Na+-H+ exchange and decrease the Na+ gradient-dependent phosphate-uptake systems in renal brush border membrane vesicles.
作者信息
Freiberg J M, Kinsella J, Sacktor B
出版信息
Proc Natl Acad Sci U S A. 1982 Aug;79(16):4932-6. doi: 10.1073/pnas.79.16.4932.
Abstract
The glucocorticoid dexamethasone, but not the mineralocorticoid aldosterone, increased amiloride-sensitive Na+-H+ exchange activity in rat proximal tubule brush border vesicles. Na+ uptake, independent of amiloride, was not affected. The glucocorticoid decreased the Na+ gradient-dependent phosphate uptake. Uptake in the absence of a Na+ gradient was not inhibited. Dexamethasone did not affect the Na+ gradient-dependent D-glucose uptake. These findings are consistent with the effects of glucocorticoids in stimulating acid secretion and causing phosphaturia in man and animals and may identify the locus of action and suggest the mechanisms by which the hormones act.
摘要
糖皮质激素地塞米松可增加大鼠近端小管刷状缘小泡中阿米洛利敏感的Na⁺-H⁺交换活性，但盐皮质激素醛固酮则无此作用。与阿米洛利无关的Na⁺摄取不受影响。糖皮质激素降低了Na⁺梯度依赖性磷酸盐摄取。在无Na⁺梯度时的摄取未受抑制。地塞米松不影响Na⁺梯度依赖性D-葡萄糖摄取。这些发现与糖皮质激素在人和动物中刺激酸分泌及导致磷酸盐尿的作用一致，可能确定了作用位点并提示了激素作用的机制。
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Glucocorticoids increase the Na+-H+ exchange and decrease the Na+ gradient-dependent phosphate-uptake systems in renal brush border membrane vesicles.糖皮质激素可增加肾刷状缘膜囊泡中的钠氢交换，并降低钠梯度依赖性磷酸盐摄取系统。
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