TMB - 8对前列腺素F2α和血栓素类似物U 46619的肺血管收缩作用的影响。
Effect of TMB-8 on the pulmonary vasoconstrictor action of prostaglandin F2 alpha and the thromboxane mimic, U 46619.
作者信息
Angerio A D, Fitzpatrick T M, Kot P A, Ramwell P W, Rose J C, Santoian E C
出版信息
Br J Pharmacol. 1982 Sep;77(1):55-8. doi: 10.1111/j.1476-5381.1982.tb09268.x.
Abstract
1 TMB-8 (8-(N,N-diethylamino)octyl-3,4,5 trimethoxybenzoate HCl), an intracellular calcium antagonist, had no direct action on the pulmonary vasculature of the perfused canine lung lobe preparation. 2 The pulmonary pressor response to the thromboxane mimic, U46619, was not affected by TMB-8. 3 The vasopressor response to prostaglandin F2 alpha (PGF 2 alpha) was significantly attenuated but not completely blocked by TMB-8. 4 We conclude that the pulmonary pressor response to PGF 2 alpha is dependent on both intracellular and extracellular calcium pools for contraction and that U46619 facilitates either solely extracellular calcium influx or mobilizes an intracellular calcium pool not inhibited by TMB-8.
摘要
- TMB - 8（8 - （N，N - 二乙氨基）辛基 - 3,4,5 - 三甲氧基苯甲酸盐酸盐），一种细胞内钙拮抗剂，对灌注犬肺叶标本的肺血管系统无直接作用。2. 对血栓素类似物U46619的肺升压反应不受TMB - 8影响。3. 对前列腺素F2α（PGF 2α）的升压反应虽被TMB - 8显著减弱但未被完全阻断。4. 我们得出结论，对PGF 2α的肺升压反应在收缩方面依赖于细胞内和细胞外钙库，且U46619要么仅促进细胞外钙内流，要么动员了一个不受TMB - 8抑制的细胞内钙库。
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