TMB - 8对前列腺素F2α和血栓素类似物U 46619的肺血管收缩作用的影响。
Effect of TMB-8 on the pulmonary vasoconstrictor action of prostaglandin F2 alpha and the thromboxane mimic, U 46619.
作者信息
Angerio A D, Fitzpatrick T M, Kot P A, Ramwell P W, Rose J C, Santoian E C
出版信息
Br J Pharmacol. 1982 Sep;77(1):55-8. doi: 10.1111/j.1476-5381.1982.tb09268.x.
Abstract
1 TMB-8 (8-(N,N-diethylamino)octyl-3,4,5 trimethoxybenzoate HCl), an intracellular calcium antagonist, had no direct action on the pulmonary vasculature of the perfused canine lung lobe preparation. 2 The pulmonary pressor response to the thromboxane mimic, U46619, was not affected by TMB-8. 3 The vasopressor response to prostaglandin F2 alpha (PGF 2 alpha) was significantly attenuated but not completely blocked by TMB-8. 4 We conclude that the pulmonary pressor response to PGF 2 alpha is dependent on both intracellular and extracellular calcium pools for contraction and that U46619 facilitates either solely extracellular calcium influx or mobilizes an intracellular calcium pool not inhibited by TMB-8.
摘要
- TMB - 8（8 - （N，N - 二乙氨基）辛基 - 3,4,5 - 三甲氧基苯甲酸盐酸盐），一种细胞内钙拮抗剂，对灌注犬肺叶标本的肺血管系统无直接作用。2. 对血栓素类似物U46619的肺升压反应不受TMB - 8影响。3. 对前列腺素F2α（PGF 2α）的升压反应虽被TMB - 8显著减弱但未被完全阻断。4. 我们得出结论，对PGF 2α的肺升压反应在收缩方面依赖于细胞内和细胞外钙库，且U46619要么仅促进细胞外钙内流，要么动员了一个不受TMB - 8抑制的细胞内钙库。
相似文献
1
Effect of TMB-8 on the pulmonary vasoconstrictor action of prostaglandin F2 alpha and the thromboxane mimic, U 46619.TMB - 8对前列腺素F2α和血栓素类似物U 46619的肺血管收缩作用的影响。
Br J Pharmacol. 1982 Sep;77(1):55-8. doi: 10.1111/j.1476-5381.1982.tb09268.x.
2
Effects of intracellular and extracellular calcium blockers on the pulmonary vascular responses to PGF2 alpha and U46619.细胞内和细胞外钙阻滞剂对肺血管对前列腺素F2α和U46619反应的影响。
Angiology. 1987 Jan;38(1 Pt 1):51-5. doi: 10.1177/000331978703800107.
3
Role of calcium in U 46619 and PGF2 alpha pulmonary vasoconstriction in rat lungs.
Am J Physiol. 1989 Dec;257(6 Pt 2):H2001-5. doi: 10.1152/ajpheart.1989.257.6.H2001.
4
Effect of verapamil on the pulmonary vasoconstrictor action of prostaglandin F2 alpha and a synthetic PGH2 analogue.维拉帕米对前列腺素F2α和一种合成PGH2类似物的肺血管收缩作用的影响。
Br J Pharmacol. 1981 May;73(1):101-3. doi: 10.1111/j.1476-5381.1981.tb16777.x.
5
Calmodulin inhibitors and 8-(N,N-diethylamino)-octyl-3,4,5-trimethoxybenzoate do not prevent the inhibitory effect of prostaglandin F2 alpha on cyclic AMP production in isolated rat corpora lutea.
J Endocrinol. 1987 May;113(2):205-12. doi: 10.1677/joe.0.1130205.
6
Influence of TMB-8 and thapsigargin on vasoconstrictor responses in the pulmonary vascular bed of the cat.TMB - 8和毒胡萝卜素对猫肺血管床血管收缩反应的影响。
Am J Ther. 2005 Sep-Oct;12(5):411-6. doi: 10.1097/01.mjt.0000132255.26146.30.
7
Effect of cyclooxygenase inhibition on the pulmonary vasodilator response to furosemide.环氧合酶抑制对肺血管舒张反应至呋塞米的影响。
J Pharmacol Exp Ther. 1988 Jul;246(1):102-6.
8
8-Diethylamino-octyl-3,4,5-trimethoxybenzoate, a calcium store blocker, increases calcium influx, inhibits alpha-1 adrenergic receptor calcium mobilization, and alters iodide transport in FRTL-5 rat thyroid cells.8-二乙氨基辛基-3,4,5-三甲氧基苯甲酸酯，一种钙储存阻滞剂，可增加钙内流，抑制α-1肾上腺素能受体介导的钙动员，并改变FRTL-5大鼠甲状腺细胞中的碘转运。
Endocrinology. 1991 Jul;129(1):542-9. doi: 10.1210/endo-129-1-542.
9
Effects of TMB-8, a calcium antagonist, on transport properties of the isolated canine tracheal epithelium.钙拮抗剂TMB - 8对离体犬气管上皮转运特性的影响。
Biochim Biophys Acta. 1987 Dec 11;905(2):311-9. doi: 10.1016/0005-2736(87)90459-7.
10
Phenol red is a thromboxane A2/prostaglandin H2 receptor antagonist in canine lingual arteries and human platelets.酚红是犬舌动脉和人血小板中的血栓素A2/前列腺素H2受体拮抗剂。
J Pharmacol Exp Ther. 1994 Mar;268(3):1352-61.
引用本文的文献
1
Neryl butyrate induces contractile effects on isolated preparations of rat aorta.正丁酸石竹烯对大鼠主动脉分离标本有收缩作用。
Naunyn Schmiedebergs Arch Pharmacol. 2020 Jan;393(1):43-55. doi: 10.1007/s00210-019-01709-z. Epub 2019 Aug 16.
本文引用的文献
1
Effect of verapamil on the pulmonary vasoconstrictor action of prostaglandin F2 alpha and a synthetic PGH2 analogue.维拉帕米对前列腺素F2α和一种合成PGH2类似物的肺血管收缩作用的影响。
Br J Pharmacol. 1981 May;73(1):101-3. doi: 10.1111/j.1476-5381.1981.tb16777.x.
2
Ca2+ movements in smooth muscle.平滑肌中的钙离子运动
Chest. 1980 Jul;78(1 Suppl):157-65. doi: 10.1378/chest.78.1_supplement.157.
3
Calcium pools utilized for contraction in smooth muscle.平滑肌收缩所利用的钙池。
Am J Physiol. 1967 Nov;213(5):1299-304. doi: 10.1152/ajplegacy.1967.213.5.1299.
4
Pharmacological evaluation of a new Ca2+ antagonist, 8-(N,N-diethylamino)-octyl-3,4,5-trimethoxybenzoate hydrochloride (TMB-8): studies in smooth muscles.新型钙离子拮抗剂盐酸8-（N，N-二乙氨基）辛基-3,4,5-三甲氧基苯甲酸酯（TMB-8）的药理学评价：平滑肌研究
Eur J Pharmacol. 1974 Jun;27(1):25-33. doi: 10.1016/0014-2999(74)90198-8.
5
Relative contributions of Ca2+ influx and cellular Ca2+ release during drug induced activation of the rabbit aorta.药物诱导兔主动脉激活过程中Ca2+内流和细胞内Ca2+释放的相对贡献。
Pflugers Arch. 1974 Apr 4;348(1):13-22. doi: 10.1007/BF00587735.
6
Studies on the mechanism of action of a new Ca-2+ antagonist, 8-(N,N-diethylamino)octyl 3,4,5-trimethoxybenzoate hydrochloride in smooth and skeletal muscles.新型钙拮抗剂盐酸8-(N,N-二乙氨基)辛基3,4,5-三甲氧基苯甲酸酯在平滑肌和骨骼肌中的作用机制研究
Br J Pharmacol. 1975 Feb;53(2):279-85. doi: 10.1111/j.1476-5381.1975.tb07359.x.
7
Cardiovascular responses to three prostaglandin endoperoxide analogs in the dog.犬对三种前列腺素内过氧化物类似物的心血管反应。
Proc Soc Exp Biol Med. 1976 Nov;153(2):209-12. doi: 10.3181/00379727-153-39512.
8
Agonist induced release of intracellular Ca2+ in the rabbit aorta.激动剂诱导兔主动脉细胞内钙离子释放。
J Membr Biol. 1977 Jan 28;30(4):363-80. doi: 10.1007/BF01869677.
9
Mechanisms of action of transmitters and other substances on smooth muscle.递质及其他物质对平滑肌的作用机制
Physiol Rev. 1979 Jul;59(3):606-718. doi: 10.1152/physrev.1979.59.3.606.
Zotero 插件