Ferstandig L L
Acta Anaesthesiol Scand Suppl. 1982;75:38-43. doi: 10.1111/j.1399-6576.1982.tb01880.x.
The epidemiologic surveys which predict morbidity for OR personnel are seriously flawed. The more carefully designed mortality studies which were based on examination of death certificates and medical records, and in one case was a prospective study, find anesthesiologists to be a healthy group with lower mortality rates than their peers and unexceptionable levels of neoplastic disease. The animal studies show that near clinical levels of anesthetics are needed during gestation to cause reproductive problems. Other animal studies show that repeated exposures to high subclinical levels of anesthetics cause no increased incidence of neoplasia. To the question: "Do traces of anesthetics present an occupational health hazard to operating room personnel?", the acceptable available evidence requires a negative answer.
预测手术室工作人员发病率的流行病学调查存在严重缺陷。那些设计更为严谨的死亡率研究，基于对死亡证明和病历的审查，其中一项还是前瞻性研究，结果发现麻醉医生是健康群体，其死亡率低于同行，且肿瘤疾病水平无可指摘。动物研究表明，孕期需要接近临床剂量的麻醉剂才会导致生殖问题。其他动物研究表明，反复接触高亚临床剂量的麻醉剂不会增加肿瘤发生率。对于“麻醉剂残留是否对手术室工作人员构成职业健康危害？”这一问题，现有可接受的证据给出了否定答案。
