Parkin J L, Arthur D C, Abramson C S, McKenna R W, Kersey J H, Heideman R L, Brunning R D
Blood. 1982 Dec;60(6):1321-31.
The acute leukemia associated with the t(4;11) chromosome rearrangement is characterized by relatively consistent clinical features: occurrence primarily in young individuals, hyperleukocytosis, and poor response to therapy. This study describes the morphological, ultrastructural, and immunologic characteristics of the leukemic cells from ten patients with this type of leukemia. The morphological features of the leukemic blasts vary from lymphoid-appearing to monocytic. Ultrastructurally and cytochemically, some of the lymphoid-appearing blasts possess features of myeloid origin. The immunologic phenotype is characteristically E- SIg- CALLA- BA-1- BA-2+ HLA-DR+ and TdT+. These findings suggest that the t(4;11)-associated acute leukemia represents a proliferation of an early myeloid progenitor cell.
与t(4;11)染色体重排相关的急性白血病具有相对一致的临床特征：主要发生于年轻人，白细胞增多，对治疗反应不佳。本研究描述了10例此类白血病患者白血病细胞的形态学、超微结构和免疫学特征。白血病原始细胞的形态学特征从类似淋巴细胞到单核细胞不等。在超微结构和细胞化学方面，一些类似淋巴细胞的原始细胞具有髓系起源的特征。免疫表型特征为E-SIg-CALLA-BA-1-BA-2+HLA-DR+和TdT+。这些发现提示，与t(4;11)相关的急性白血病代表早期髓系祖细胞的增殖。
