Budowle B, Acton R T, Barger B O, Blackstock R, Crist W, Go R C, Humphrey G B, Ragab A, Roper M, Vietti T, Dearth J
Cancer. 1982 Dec 1;50(11):2369-71. doi: 10.1002/1097-0142(19821201)50:11<2369::aid-cncr2820501123>3.0.co;2-s.
One hundred-sixty-four ALL patients were compared to 545 controls for differences in phenotype and gene frequencies at the Properdin factor B locus. In addition, 90 of the ALL patients were immune phenotyped. A significant association with the Bf F allele and ALL was found, resulting in an estimated relative risk of 3.62. There was no difference in the Bf S phenotype between ALL patients and controls. However, those homozygous for the Bf S allele are at a significantly low risk of 0.30 for developing ALL. ALL patients with a non-B/T cell type were 2.5 times more likely to be Bf SS homozygotes; in contrast, those patients with the pre-B cell type were 2.5 more likely to be Bf FF homozygotes. These data suggest association of the Bf locus with an ALL protection and/or susceptibility gene(s).
将164例急性淋巴细胞白血病（ALL）患者与545名对照者进行比较，分析备解素因子B基因座的表型和基因频率差异。此外，对90例ALL患者进行了免疫表型分析。结果发现，Bf F等位基因与ALL之间存在显著关联，估计相对风险为3.62。ALL患者和对照者之间的Bf S表型没有差异。然而，Bf S等位基因纯合子发生ALL的风险显著降低，为0.30。非B/T细胞类型的ALL患者成为Bf SS纯合子的可能性是其他患者的2.5倍；相反，前B细胞类型的患者成为Bf FF纯合子的可能性高2.5倍。这些数据表明Bf基因座与ALL保护和/或易感基因相关。
