两名慢性粒细胞白血病患者的费城染色体变异易位

Variant Philadelphia chromosome translocations in two patients with chronic myelogenous leukemia.

作者信息

Testa J R, Jumamoy L M, Wiernik P H

出版信息

Cancer Genet Cytogenet. 1982 Sep;7(1):79-84. doi: 10.1016/0165-4608(82)90111-x.

Abstract

Two patients with chronic myelogenous leukemia and new variant Philadelphia chromosome translocations are reported. In one case, a 41-year-old male, a 10;22 translocation was found in all bone marrow cells examined. Furthermore, the Y chromosome was missing in 90% of the analyzed metaphase cells. In the second patient, a 22-year-old male, all the marrow cells contained a complex rearrangement involving chromosomes No. 2, 9 and 22.

摘要

报告了两名患有慢性粒细胞白血病且有新型费城染色体易位的患者。其中一例，一名41岁男性，在所检查的所有骨髓细胞中发现了10号与22号染色体的易位。此外，在90%的分析中期细胞中Y染色体缺失。第二例患者是一名22岁男性，所有骨髓细胞都含有涉及2号、9号和22号染色体的复杂重排。