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由易位(9;11;22)导致的隐匿性费城染色体。

Masked Philadelphia chromosome caused by translocation (9;11;22).

作者信息

Sessarego M, Pasquali F, Bianchi Scarrà G L, Ajmar F

出版信息

Cancer Genet Cytogenet. 1983 Apr;8(4):319-23. doi: 10.1016/0165-4608(83)90074-2.

Abstract

In a patient with chronic myelocytic leukemia (CML), chromosome analysis revealed a translocation involving chromosomes No. 9, 11, and 22, with three break points, thus giving origin to a so-called "masked" Philadelphia chromosome (Ph1). A review of similar cases reported in the literature indicates that a masked Ph1 is very rare, that the chromosomes involved vary from case to case, and that in most cases the pattern of the rearrangement is quite different from that of two- and three-chromosome variant Ph1 translocations.

摘要

在一名慢性粒细胞白血病(CML)患者中,染色体分析显示9号、11号和22号染色体发生易位,有三个断点,从而产生了所谓的“隐匿型”费城染色体(Ph1)。对文献中报道的类似病例的回顾表明,隐匿型Ph1非常罕见,所涉及的染色体因病例而异,并且在大多数情况下,重排模式与两染色体和三染色体变异型Ph1易位的模式有很大不同。

相似文献

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Three chromosomes' (7;9;22) rearrangement and the origin of the Philadelphia chromosome.
Hum Genet. 1978 Aug 31;43(2):133-7. doi: 10.1007/BF00293590.
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New types of unusual and complex Philadelphia chromosome (Ph1) translocations in chronic myeloid leukemia.
Cancer Genet Cytogenet. 1981 Jan;3(1):19-31. doi: 10.1016/0165-4608(81)90052-2.

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