Brincker H
Scand J Haematol. 1982 Sep;29(3):241-9. doi: 10.1111/j.1600-0609.1982.tb00589.x.
Due to recent developments in clinical haematology, 98.8% of all 1980 cases of leukaemia reported to the Danish Cancer Registry during the 4-year period 1973-76 could be subclassified into the 4 main types of leukaemia. Thus, it has been possible to characterize each of these types more accurately than before regarding age- and sex-specific incidence rates, relative frequency, male/female ratio, and median age at diagnosis. Chronic lymphatic leukaemia constituted 38% and chronic myeloid leukaemia 15% of the cases. These figures are larger and smaller, respectively, than these previously reported. The median age of all cases combined was 67 years, and the median age in cases of acute non-lymphocytic leukaemia was 64 years with 59% of the latter patients more than 60 years of age. In childhood myeloid leukaemia, an early incidence peak, not previously described, was observed before the age of 2 years. Analysis of Danish leukaemia incidence rates from 1943 and onwards shows no increase over 3 decades in patients less than 75 years of age. Thus, the observed increase in incidence from 5866-9942/100 000 during the period studied is limited to the very oldest age groups and is probably due to improved diagnostic efforts.
由于临床血液学的最新进展，在1973 - 1976年这4年期间向丹麦癌症登记处报告的所有1980例白血病病例中，98.8%可细分为4种主要白血病类型。因此，就年龄和性别特异性发病率、相对频率、男女比例以及诊断时的中位年龄而言，已能够比以往更准确地描述每种类型。慢性淋巴细胞白血病占病例的38%，慢性粒细胞白血病占15%。这些数字分别比之前报告的数字大或小。所有病例合并后的中位年龄为67岁，急性非淋巴细胞白血病病例的中位年龄为64岁，其中59%的患者年龄超过60岁。在儿童髓系白血病中，观察到在2岁之前出现了一个以前未描述过的早期发病高峰。对1943年及以后丹麦白血病发病率的分析表明，75岁以下患者在30年期间发病率没有增加。因此，在研究期间观察到的发病率从5866 - 9942/10万的增加仅限于最年长的年龄组，可能是由于诊断工作的改进。
