van Steensel-Moll H A, Valkenburg H A, van Zanen G E
Br J Cancer. 1983 Apr;47(4):471-5. doi: 10.1038/bjc.1983.76.
The childhood leukaemia incidence rate for the Netherlands was estimated at 3.11 per 100.000 children (aged 0-15 year) per year, based on a complete nation-wide childhood leukaemia registry comprising the period 1973-1980. Acute lymphocytic leukaemia (ALL) accounted for 82.4% of the patients, acute non-lymphocytic leukaemia for 13.6% and chronic myeloid leukaemia for 2.9%. ALL occurred more frequently in boys (sex ratio 1.2). The highest ALL rate was observed in the 3-4 year age group. These figures corresponded with the data of the Manchester Children's Tumour Registry. Neither the incidence rates according to year of diagnosis nor the incidence rates according to year of birth showed a significant trend with time. The total leukaemia incidence rate in urban areas was somewhat higher than in rural areas. While the direct comparison of the incidence rate between these areas is not significant, the trend over the three categories of urbanisation is significant.
根据1973年至1980年期间完整的全国儿童白血病登记数据，荷兰儿童白血病发病率估计为每年每10万名儿童（0至15岁）中有3.11例。急性淋巴细胞白血病（ALL）占患者的82.4%，急性非淋巴细胞白血病占13.6%，慢性粒细胞白血病占2.9%。ALL在男孩中更为常见（性别比为1.2）。在3至4岁年龄组中观察到最高的ALL发病率。这些数字与曼彻斯特儿童肿瘤登记处的数据一致。根据诊断年份和出生年份的发病率均未显示出随时间的显著趋势。城市地区的白血病总发病率略高于农村地区。虽然这些地区之间发病率的直接比较不显著，但城市化三类地区的趋势是显著的。
