Takagi M, Ishikawa G
Bull Tokyo Med Dent Univ. 1982 Dec;29(4):103-11.
Two autopsy cases are presented of spindle-cell carcinoma of the oral cavity, which were transformations from the pre-existing well differentiated squamous cell carcinoma in Case 1 and verrucous carcinoma in Case 2, after large doses of irradiation. In Case 2, the conventional squamous cell carcinoma existed at the time of biopsy. Our case study suggests that the spindle-cell carcinoma may develop from the verrucous carcinoma by dedifferentiation through the intermediate stage of conventional squamous cell carcinoma.
本文报告了两例口腔梭形细胞癌的尸检病例，病例1由先前存在的高分化鳞状细胞癌转变而来，病例2由疣状癌转变而来，均在大剂量放疗后发生。在病例2中，活检时存在传统鳞状细胞癌。我们的病例研究表明，梭形细胞癌可能通过传统鳞状细胞癌的中间阶段去分化，从疣状癌发展而来。
