Baden E, Bouissou H, Pieraggi M T, Julian M
J Biol Buccale. 1982 Sep;10(3):227-35.
The effects of chronic toxicity of beta-aminoproprionitrile (BAPN) on the lingual artery and aorta of the rat were compared. Thirty-two three week old weanling male white Wistar rats were given 1 g/kg/day (for five days weekly) of a 40% saturated solution of BAPN fumarate by intragastric tube. The animals were divided into four groups of eight animals each and sacrificed after one, three, six and nine weeks respectively. For each group, four controls were used. Cross-sections of the lingual artery and aorta stained with hematoxylin-erythrosin-safranin, alcian blue, Masson's trichrome and Verhoeff's iron hematoxylin were studied. BAPN had no effect on the lingual artery. Early changes were seen in the aorta at six weeks. Characteristic lesions were found at nine weeks involving the elastic tissue, myocytes and ground substance. The elastic lamellae were thinner, lost their normal orientation, and became swollen and finally fragmented. The myocytes of the media changed orientation and migrated into the intima. The proteoglycans increased and fibrosis supervened at the end stage. Failure to induce lesions in the lingual artery may be explained by early structural maturation and a low metabolic turnover rate in muscular arteries, decreased exposure to or greater protection from mechanical stress.
比较了β-氨基丙腈（BAPN）对大鼠舌动脉和主动脉的慢性毒性作用。32只3周龄断乳雄性白色Wistar大鼠通过胃管给予1 g/kg/天（每周5天）的40%富马酸BAPN饱和溶液。将动物分为四组，每组8只，分别在1、3、6和9周后处死。每组使用4只对照动物。研究了用苏木精-伊红-番红、阿尔辛蓝、马松三色染色法和韦尔霍夫铁苏木精染色的舌动脉和主动脉的横截面。BAPN对舌动脉无影响。6周时主动脉出现早期变化。9周时发现特征性病变，累及弹性组织、心肌细胞和基质。弹性板变薄，失去正常方向，肿胀并最终破碎。中膜的心肌细胞改变方向并迁移至内膜。蛋白聚糖增加，终末期出现纤维化。舌动脉未诱导病变可能是由于肌肉动脉早期结构成熟和代谢周转率低、机械应力暴露减少或受到更大保护。
