Baden E, Bouissou H
College of Dental Medicine, Fairleigh Dickinson University, Hackensack, NJ.
Ann Pathol. 1987;7(4-5):297-303.
The effect of chronic lathyrism on the mandible of the rat was studied. Exostoses, thinning and discoloration of the cortical plates, intraosseous bleeding and hemorrhagic cyst were observed after six weeks of administration of beta-aminoproprionitrile fumarate. The exostoses consisted of homogeneous cellular fibrous tissue containing osteoid, hyalin-like material and abundant ground substance. The cysts were filled with erythrocytes and lined by spindle-shaped fibroblasts, collagen fibers or osteoblast-like cells. Between the cysts, bands and sheets of dense and cellular connective tissue presenting foci of hemorrhage, osteoid and metaplastic cartilage were found. Numerous mast cells were demonstrated with alcian and toluidine blue in the hematopoietic bone marrow, cancellous bone and around the capillary network surrounding the exostoses and cysts. Exostoses have already been studied and explained by the action of BAPN (lysyl oxidase). Hemorrhagic cysts could be explained by histamine release from the mast cells (hypervascularity, hyperemia, increased permeability, rupture and progressive confluence of these small hemorrhagic cysts). Histopathology of the experimental cysts had some points in common with the human aneurysmal bone cyst. Could the pathogenic mechanisms be similar for both lesions?
研究了慢性山黧豆中毒对大鼠下颌骨的影响。给予富马酸β-氨基丙腈六周后，观察到骨赘、皮质板变薄和变色、骨内出血及出血性囊肿。骨赘由含有类骨质、透明样物质和丰富基质的均匀细胞性纤维组织构成。囊肿内充满红细胞，内衬梭形成纤维细胞、胶原纤维或成骨细胞样细胞。在囊肿之间，发现有密集的细胞性结缔组织带和片层，伴有出血灶、类骨质和化生软骨。用阿尔辛蓝和甲苯胺蓝在造血骨髓、松质骨以及骨赘和囊肿周围的毛细血管网周围证实有大量肥大细胞。骨赘已经通过BAPN（赖氨酰氧化酶）的作用进行了研究和解释。出血性囊肿可以通过肥大细胞释放组胺来解释（这些小出血性囊肿的血管增多、充血、通透性增加、破裂和逐渐融合）。实验性囊肿的组织病理学与人类动脉瘤性骨囊肿有一些共同之处。这两种病变的致病机制会相似吗？
