Block L H, Vetter W, Siegenthaler W
Klin Wochenschr. 1982 Nov 15;60(22):1373-84. doi: 10.1007/BF01716242.
Immunopharmacological effects of corticosteroids are primarily dependent upon their capacity to modify inflammatory reactions at various levels. Their molecular effects are related to the vascular system and to lymphocytes, phagocytes and mast cells, all cell types being involved in inflammation. They modulate the physiology, molecular biology and membrane dynamics of these cells thereby influencing cellular and humoral immune functions. The complexity of these effects may at least partially explain the usefulness of corticosteroids in cases of immunoproliferative, autoimmune and allergic disorders.
皮质类固醇的免疫药理作用主要取决于它们在不同水平上调节炎症反应的能力。它们的分子效应与血管系统以及淋巴细胞、吞噬细胞和肥大细胞有关,所有这些细胞类型都参与炎症反应。它们调节这些细胞的生理学、分子生物学和膜动力学,从而影响细胞免疫和体液免疫功能。这些效应的复杂性至少可以部分解释皮质类固醇在免疫增殖性、自身免疫性和过敏性疾病中的有用性。