Olson J A, Feinberg I, Silverman S, Abrams D, Greenspan J S
Oral Surg Oral Med Oral Pathol. 1982 Nov;54(5):517-20. doi: 10.1016/0030-4220(82)90189-x.
Hematologic deficiencies have previously been described in some cases of recurrent aphthous ulceration (RAU). Ninety patients with RAU and twenty-three healthy control subjects were evaluated by complete blood count, serum iron, and total iron-binding capacity, serum vitamin B12, and serum or red blood cell folate. Only three of ninety RAU patients proved to have abnormalities. There were no statistically significant differences between the patient and control populations, and no one in either group had abnormal serum vitamin B12 or serum or RBC folate assays. None of the patients or controls gave a history or symptoms suggestive of iron-deficiency or megaloblastic anemia, and all were without gastrointestinal complaints. These results suggest that hematologic tests other than a complete blood count are not routinely indicated for patients with RAU.
血液学缺陷先前在一些复发性阿弗他溃疡（RAU）病例中已有描述。通过全血细胞计数、血清铁、总铁结合力、血清维生素B12以及血清或红细胞叶酸对90例RAU患者和23名健康对照者进行了评估。90例RAU患者中仅有3例被证实存在异常。患者群体与对照群体之间无统计学显著差异，两组中均无人血清维生素B12或血清或红细胞叶酸检测异常。患者和对照者均无缺铁或巨幼细胞贫血的病史或症状提示，且所有人均无胃肠道不适。这些结果表明，对于RAU患者，除全血细胞计数外的血液学检查并非常规必需。
