The effect of the phenytoin metabolite p-HPPH on proliferation of gingival fibroblasts in vitro.
作者信息
Modéer T, Dahllöf G, Otteskog P
出版信息
Acta Odontol Scand. 1982;40(5):353-7. doi: 10.3109/00016358209024080.
PMID:6960635
Abstract
The effect of the major phenytoin metabolite-5-(parahydroxyphenyl)-5-phenylhydantoin (p-HPPH) was studied on cultures on human fibroblast-like cells grown out from explanted gingival biopsies. The explants were taken from children undergoing phenytoin medication. The results showed that the number of cells per culture decreased whereas the protein and DNA-contents remained relatively unaffected. This effect was most pronounced at the concentrations of 0.20 micrograms/ml p-HPPH. The results indicate that the metabolite interfere with cell division without affecting protein or DNA synthesis.
摘要
相似文献
1
The effect of the phenytoin metabolite p-HPPH on proliferation of gingival fibroblasts in vitro.
Acta Odontol Scand. 1982;40(5):353-7. doi: 10.3109/00016358209024080.
2
The phenytoin metabolite p-HPPH upregulates prostaglandin biosynthesis in human gingival fibroblasts challenged to interleukin-1.苯妥英代谢物对羟基苯妥英在受到白细胞介素-1刺激的人牙龈成纤维细胞中上调前列腺素生物合成。
Life Sci. 1993;53(6):503-15. doi: 10.1016/0024-3205(93)90702-5.
3
Phenytoin and 5-(p-hydroxyphenyl)-5-phenylhydantoin do not alter the effects of bacterial and amplified plaque extracts on cultures of fibroblasts from normal and overgrown gingivae.苯妥英和5-（对羟基苯基）-5-苯基乙内酰脲不会改变细菌和扩增菌斑提取物对正常和过度生长牙龈成纤维细胞培养物的影响。
J Dent Res. 1987 Aug;66(8):1393-8. doi: 10.1177/00220345870660082201.
4
Potentiation of fibroblast DNA synthesis by a phenytoin-induced mononuclear cell derived factor in vitro.苯妥英诱导的单核细胞衍生因子在体外增强成纤维细胞DNA合成
Scand J Dent Res. 1989 Apr;97(2):186-7. doi: 10.1111/j.1600-0722.1989.tb01448.x.
5
Effect of 5-(p-hydroxyphenyl)-5-phenylhydantoin (p-HPPH) enantiomers, major metabolites of phenytoin, on the occurrence of chronic-gingival hyperplasia: in vivo and in vitro study.
Eur J Clin Pharmacol. 1995;49(1-2):51-6. doi: 10.1007/BF00192358.
6
Effect of calcium-channel blockers on cell proliferation, DNA synthesis and collagen synthesis of cultured gingival fibroblasts derived from human nifedipine responders and non-responders.
Arch Oral Biol. 1994 Feb;39(2):99-104. doi: 10.1016/0003-9969(94)90103-1.
7
Effect of phenytoin on interleukin-1 beta production in human gingival fibroblasts challenged to tumor necrosis factor alpha in vitro.苯妥英对体外受肿瘤坏死因子α刺激的人牙龈成纤维细胞中白细胞介素-1β产生的影响。
Eur J Oral Sci. 1996 Feb;104(1):27-33. doi: 10.1111/j.1600-0722.1996.tb00042.x.
8
Phenytoin and cyclosporin A suppress the expression of MMP-1, TIMP-1, and cathepsin L, but not cathepsin B in cultured gingival fibroblasts.苯妥英钠和环孢素A可抑制培养的牙龈成纤维细胞中基质金属蛋白酶-1、金属蛋白酶组织抑制剂-1和组织蛋白酶L的表达，但不影响组织蛋白酶B的表达。
J Periodontol. 2000 Jun;71(6):955-60. doi: 10.1902/jop.2000.71.6.955.
9
Effect of phenytoin on mitotic activity of gingival tissue and cultured fibroblasts.
J Periodontol. 1981 Dec;52(12):747-9. doi: 10.1902/jop.1981.52.12.747.
10
Metabolism of phenytoin by the gingiva of normal humans: the possible role of reactive metabolites of phenytoin in the initiation of gingival hyperplasia.
Clin Pharmacol Ther. 1996 Aug;60(2):191-8. doi: 10.1016/S0009-9236(96)90135-6.
引用本文的文献
1
Prevention of phenytoin-induced gingival overgrowth by lovastatin in mice.洛伐他汀对小鼠苯妥英钠诱导的牙龈过度生长的预防作用
Am J Pathol. 2015 Jun;185(6):1588-99. doi: 10.1016/j.ajpath.2015.02.004. Epub 2015 Apr 2.
2
Effect of 5-(p-hydroxyphenyl)-5-phenylhydantoin (p-HPPH) enantiomers, major metabolites of phenytoin, on the occurrence of chronic-gingival hyperplasia: in vivo and in vitro study.
Eur J Clin Pharmacol. 1995;49(1-2):51-6. doi: 10.1007/BF00192358.
3
Interleukin-1 beta induces expression of cyclooxygenase-2 mRNA in human gingival fibroblasts.白细胞介素-1β诱导人牙龈成纤维细胞中环氧合酶-2 mRNA的表达。
Inflammation. 1995 Oct;19(5):549-60. doi: 10.1007/BF01539135.
4
Bradykinin B1 and B2 receptor agonists synergistically potentiate interleukin-1-induced prostaglandin biosynthesis in human gingival fibroblasts.
Inflammation. 1991 Dec;15(6):427-36. doi: 10.1007/BF00923340.
5
Phenytoin potentiates interleukin-1-induced prostaglandin biosynthesis in human gingival fibroblasts.苯妥英可增强白细胞介素-1诱导的人牙龈成纤维细胞中前列腺素的生物合成。
Br J Pharmacol. 1992 Jul;106(3):574-8. doi: 10.1111/j.1476-5381.1992.tb14377.x.
6
Bradykinin induces a B2 receptor-mediated calcium signal linked to prostanoid formation in human gingival fibroblasts in vitro.
Agents Actions. 1992 Sep;37(1-2):44-52. doi: 10.1007/BF01987889.
Zotero 插件