• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The effect of the phenytoin metabolite p-HPPH on proliferation of gingival fibroblasts in vitro.

作者信息

Modéer T, Dahllöf G, Otteskog P

出版信息

Acta Odontol Scand. 1982;40(5):353-7. doi: 10.3109/00016358209024080.

DOI:10.3109/00016358209024080
PMID:6960635
Abstract

The effect of the major phenytoin metabolite-5-(parahydroxyphenyl)-5-phenylhydantoin (p-HPPH) was studied on cultures on human fibroblast-like cells grown out from explanted gingival biopsies. The explants were taken from children undergoing phenytoin medication. The results showed that the number of cells per culture decreased whereas the protein and DNA-contents remained relatively unaffected. This effect was most pronounced at the concentrations of 0.20 micrograms/ml p-HPPH. The results indicate that the metabolite interfere with cell division without affecting protein or DNA synthesis.

摘要

相似文献

1
The effect of the phenytoin metabolite p-HPPH on proliferation of gingival fibroblasts in vitro.
Acta Odontol Scand. 1982;40(5):353-7. doi: 10.3109/00016358209024080.
2
The phenytoin metabolite p-HPPH upregulates prostaglandin biosynthesis in human gingival fibroblasts challenged to interleukin-1.苯妥英代谢物对羟基苯妥英在受到白细胞介素-1刺激的人牙龈成纤维细胞中上调前列腺素生物合成。
Life Sci. 1993;53(6):503-15. doi: 10.1016/0024-3205(93)90702-5.
3
Phenytoin and 5-(p-hydroxyphenyl)-5-phenylhydantoin do not alter the effects of bacterial and amplified plaque extracts on cultures of fibroblasts from normal and overgrown gingivae.苯妥英和5-（对羟基苯基）-5-苯基乙内酰脲不会改变细菌和扩增菌斑提取物对正常和过度生长牙龈成纤维细胞培养物的影响。
J Dent Res. 1987 Aug;66(8):1393-8. doi: 10.1177/00220345870660082201.
4
Potentiation of fibroblast DNA synthesis by a phenytoin-induced mononuclear cell derived factor in vitro.苯妥英诱导的单核细胞衍生因子在体外增强成纤维细胞DNA合成
Scand J Dent Res. 1989 Apr;97(2):186-7. doi: 10.1111/j.1600-0722.1989.tb01448.x.
5
Effect of 5-(p-hydroxyphenyl)-5-phenylhydantoin (p-HPPH) enantiomers, major metabolites of phenytoin, on the occurrence of chronic-gingival hyperplasia: in vivo and in vitro study.
Eur J Clin Pharmacol. 1995;49(1-2):51-6. doi: 10.1007/BF00192358.
6
Effect of calcium-channel blockers on cell proliferation, DNA synthesis and collagen synthesis of cultured gingival fibroblasts derived from human nifedipine responders and non-responders.
Arch Oral Biol. 1994 Feb;39(2):99-104. doi: 10.1016/0003-9969(94)90103-1.
7
Effect of phenytoin on interleukin-1 beta production in human gingival fibroblasts challenged to tumor necrosis factor alpha in vitro.苯妥英对体外受肿瘤坏死因子α刺激的人牙龈成纤维细胞中白细胞介素-1β产生的影响。
Eur J Oral Sci. 1996 Feb;104(1):27-33. doi: 10.1111/j.1600-0722.1996.tb00042.x.
8
Phenytoin and cyclosporin A suppress the expression of MMP-1, TIMP-1, and cathepsin L, but not cathepsin B in cultured gingival fibroblasts.苯妥英钠和环孢素A可抑制培养的牙龈成纤维细胞中基质金属蛋白酶-1、金属蛋白酶组织抑制剂-1和组织蛋白酶L的表达，但不影响组织蛋白酶B的表达。
J Periodontol. 2000 Jun;71(6):955-60. doi: 10.1902/jop.2000.71.6.955.
9
Effect of phenytoin on mitotic activity of gingival tissue and cultured fibroblasts.
J Periodontol. 1981 Dec;52(12):747-9. doi: 10.1902/jop.1981.52.12.747.
10
Metabolism of phenytoin by the gingiva of normal humans: the possible role of reactive metabolites of phenytoin in the initiation of gingival hyperplasia.
Clin Pharmacol Ther. 1996 Aug;60(2):191-8. doi: 10.1016/S0009-9236(96)90135-6.

引用本文的文献

1
Prevention of phenytoin-induced gingival overgrowth by lovastatin in mice.洛伐他汀对小鼠苯妥英钠诱导的牙龈过度生长的预防作用
Am J Pathol. 2015 Jun;185(6):1588-99. doi: 10.1016/j.ajpath.2015.02.004. Epub 2015 Apr 2.
2
Effect of 5-(p-hydroxyphenyl)-5-phenylhydantoin (p-HPPH) enantiomers, major metabolites of phenytoin, on the occurrence of chronic-gingival hyperplasia: in vivo and in vitro study.
Eur J Clin Pharmacol. 1995;49(1-2):51-6. doi: 10.1007/BF00192358.
3
Interleukin-1 beta induces expression of cyclooxygenase-2 mRNA in human gingival fibroblasts.白细胞介素-1β诱导人牙龈成纤维细胞中环氧合酶-2 mRNA的表达。
Inflammation. 1995 Oct;19(5):549-60. doi: 10.1007/BF01539135.
4
Bradykinin B1 and B2 receptor agonists synergistically potentiate interleukin-1-induced prostaglandin biosynthesis in human gingival fibroblasts.
Inflammation. 1991 Dec;15(6):427-36. doi: 10.1007/BF00923340.
5
Phenytoin potentiates interleukin-1-induced prostaglandin biosynthesis in human gingival fibroblasts.苯妥英可增强白细胞介素-1诱导的人牙龈成纤维细胞中前列腺素的生物合成。
Br J Pharmacol. 1992 Jul;106(3):574-8. doi: 10.1111/j.1476-5381.1992.tb14377.x.
6
Bradykinin induces a B2 receptor-mediated calcium signal linked to prostanoid formation in human gingival fibroblasts in vitro.
Agents Actions. 1992 Sep;37(1-2):44-52. doi: 10.1007/BF01987889.