Hermanns W, Schulz L C
Agents Actions Suppl. 1982;11:117-29.
The cytogenetic relationship between synovial lining cell type A and macrophages both involved in joint destruction is still obscure. By means of enzyme histochemistry we tried to demonstrate marker enzymes of macrophages, like non-specific esterase and acid phosphatase in lining cells of normal and arthritic rats too. The pattern of esterase-positive cells depends on the arrangement of the lining cell layer. In flat layers single cells and in compact layers the upper row of cells react positively. The activity of acid phosphatase is negligible as compared with macrophages in liver, lung, or spleen. In arthritic joints acid phosphatase of lining cells increases and non-specific esterase concomitantly decreases. In the subsynovial tissue large amounts of esterase-positive cells occur. In these enzyme histochemical studies the pattern of marker enzymes may be indicative for a population of macrophages within the lining cell layer still under normal conditions.
参与关节破坏的A型滑膜衬里细胞与巨噬细胞之间的细胞遗传学关系仍不清楚。我们试图通过酶组织化学方法，在正常大鼠和关节炎大鼠的衬里细胞中显示巨噬细胞的标记酶，如非特异性酯酶和酸性磷酸酶。酯酶阳性细胞的模式取决于衬里细胞层的排列。在扁平层中为单个细胞，在致密层中上层细胞呈阳性反应。与肝脏、肺或脾脏中的巨噬细胞相比，酸性磷酸酶的活性可忽略不计。在关节炎关节中，衬里细胞的酸性磷酸酶增加，非特异性酯酶随之减少。在滑膜下组织中出现大量酯酶阳性细胞。在这些酶组织化学研究中，标记酶的模式可能表明在正常情况下衬里细胞层内存在一群巨噬细胞。
