Baar S
Br J Exp Pathol. 1982 Dec;63(6):644-50.
Whole blood was heated in vitro and incubated with any of the following: epinephrine, norepinephrine, prostaglandin E1, prostaglandin E2 or prostaglandin F2 alpha. The treatment was assessed by whole-blood filtration and extrusion of a Ca2+ load from Ca2+ loaded red cells. Epinephrine did not affect the parameters measured. Norepinephrine increased cell filtration times and delayed Ca2+ extrusion. Prostaglandin E1 acted in an opposite manner. prostaglandin E2 and F2 alpha both decreased red-cell deformability and Ca2+ extrusion above the effect of heat alone Prostaglandin E2 showed the most pronounced effect. Possible implications of the findings for microcirculation in burned patients are discussed.
将全血在体外加热，并与以下任何一种物质一起孵育：肾上腺素、去甲肾上腺素、前列腺素E1、前列腺素E2或前列腺素F2α。通过全血过滤和从加载钙的红细胞中挤出钙负荷来评估处理效果。肾上腺素不影响所测量的参数。去甲肾上腺素增加细胞过滤时间并延迟钙的挤出。前列腺素E1的作用方式相反。前列腺素E2和F2α均降低红细胞变形性，且在单独加热的影响之上进一步降低钙的挤出，前列腺素E2的作用最为显著。讨论了这些发现对烧伤患者微循环的可能影响。
