儿茶酚胺和前列腺素对热损伤红细胞钙外流及滤过性的影响：一项体外研究
The influence of catecholamines and prostaglandins on calcium efflux and filtrability of thermally damaged erythrocytes: an in vitro study.
作者信息
Baar S
出版信息
Br J Exp Pathol. 1982 Dec;63(6):644-50.
Abstract
Whole blood was heated in vitro and incubated with any of the following: epinephrine, norepinephrine, prostaglandin E1, prostaglandin E2 or prostaglandin F2 alpha. The treatment was assessed by whole-blood filtration and extrusion of a Ca2+ load from Ca2+ loaded red cells. Epinephrine did not affect the parameters measured. Norepinephrine increased cell filtration times and delayed Ca2+ extrusion. Prostaglandin E1 acted in an opposite manner. prostaglandin E2 and F2 alpha both decreased red-cell deformability and Ca2+ extrusion above the effect of heat alone Prostaglandin E2 showed the most pronounced effect. Possible implications of the findings for microcirculation in burned patients are discussed.
摘要
将全血在体外加热，并与以下任何一种物质一起孵育：肾上腺素、去甲肾上腺素、前列腺素E1、前列腺素E2或前列腺素F2α。通过全血过滤和从加载钙的红细胞中挤出钙负荷来评估处理效果。肾上腺素不影响所测量的参数。去甲肾上腺素增加细胞过滤时间并延迟钙的挤出。前列腺素E1的作用方式相反。前列腺素E2和F2α均降低红细胞变形性，且在单独加热的影响之上进一步降低钙的挤出，前列腺素E2的作用最为显著。讨论了这些发现对烧伤患者微循环的可能影响。
相似文献
1
2
Prostaglandins affect the central nervous system to produce hyperglycemia in rats.前列腺素影响中枢神经系统，使大鼠产生高血糖。
Endocrinology. 1987 Jul;121(1):36-41. doi: 10.1210/endo-121-1-36.
3
Examination of the filterability of oxygenated erythrocytes (containing normal, trait or sickle cell disease type hemoglobins) in the presence of L-epinephrine, D,L-isoproterenol or prostaglandins (PG) A1, A2, E1, E2, F1alpha or F2alpha.在L-肾上腺素、D,L-异丙肾上腺素或前列腺素（PG）A1、A2、E1、E2、F1α或F2α存在的情况下，对含氧红细胞（含有正常、特质或镰状细胞病类型血红蛋白）的滤过性进行检测。
Prostaglandins. 1977 Feb;13(2):281-309. doi: 10.1016/0090-6980(77)90009-0.
4
Effect of prostaglandins and their analogues on hormone-stimulated glycogenolysis in primary cultures of rat hepatocytes.前列腺素及其类似物对大鼠肝细胞原代培养物中激素刺激的糖原分解的影响。
Biochim Biophys Acta. 1988 Feb 4;958(2):179-87. doi: 10.1016/0005-2760(88)90175-0.
5
Effect of vasoactive agents on prostanoid synthesis in isolated rat glomeruli.
Isr J Med Sci. 1986 Nov;22(11):797-800.
6
The effect of catecholamines and prostaglandins upon human and rat erythrocytes.
Biochim Biophys Acta. 1975 Nov 10;411(1):63-73. doi: 10.1016/0304-4165(75)90285-8.
7
Human red blood cells: prostaglandin E2, epinephrine, and isoproterenol alter deformability.人类红细胞：前列腺素E2、肾上腺素和异丙肾上腺素会改变其可变形性。
Science. 1971 Oct 29;174(4008):512-4. doi: 10.1126/science.174.4008.512.
8
Morphometric effect of prostaglandin E1 and F2 alpha on lactating bovine mammary tissue in vitro.前列腺素E1和F2α对体外泌乳期奶牛乳腺组织的形态计量学影响
J Dairy Sci. 1984 Jan;67(1):133-9. doi: 10.3168/jds.S0022-0302(84)81276-X.
9
Effects of prostaglandins E1, E2, and F2 alpha on mucin secretion from human bronchi in vitro.前列腺素E1、E2和F2α对人支气管体外黏蛋白分泌的影响。
Thorax. 1984 Jun;39(6):420-3. doi: 10.1136/thx.39.6.420.
10
Prostaglandin I2 and E1 and red cell deformability in raynaud's phenomenon and systemic sclerosis.前列腺素I2、E1与雷诺现象和系统性硬化症中的红细胞变形性
Br Med J (Clin Res Ed). 1981 Dec 12;283(6306):1608-9. doi: 10.1136/bmj.283.6306.1608-e.
本文引用的文献
1
Histological demonstration of prostaglandins and thromboxanes in burned tissue.烧伤组织中前列腺素和血栓素的组织学证明。
J Surg Res. 1980 Feb;28(2):110-7. doi: 10.1016/0022-4804(80)90153-5.
2
ATP-dependent Ca++-extrusion from human red cells.人红细胞中依赖三磷酸腺苷的钙离子排出
Experientia. 1966 Jun 15;22(6):364-5. doi: 10.1007/BF01901136.
3
Sodium transport in human erythrocytes--absence of an effect of prostaglandin E1.人类红细胞中的钠转运——前列腺素E1无作用
Biochem Biophys Res Commun. 1971 Mar 19;42(6):1063-7. doi: 10.1016/0006-291x(71)90012-x.
4
Thermal damage to red cells.红细胞的热损伤。
J Clin Pathol. 1970 Oct;23(7):572-6. doi: 10.1136/jcp.23.7.572.
5
Human red blood cells: prostaglandin E2, epinephrine, and isoproterenol alter deformability.人类红细胞：前列腺素E2、肾上腺素和异丙肾上腺素会改变其可变形性。
Science. 1971 Oct 29;174(4008):512-4. doi: 10.1126/science.174.4008.512.
6
Intracellular cation alterations following major trauma: effect of supranormal caloric intake.严重创伤后细胞内阳离子变化：超正常热量摄入的影响
J Trauma. 1971 May;11(5):390-6. doi: 10.1097/00005373-197105000-00003.
7
Red blood cell calcium and magnesium: effects upon sodium and potassium transport and cellular morphology.红细胞钙和镁：对钠和钾转运及细胞形态的影响。
Biochim Biophys Acta. 1974 May 30;352(1):97-116. doi: 10.1016/0005-2736(74)90182-5.
8
Mechanisms of delayed red cell destruction after thermal injury. An experimental in vitro sem study.热损伤后红细胞延迟破坏的机制。一项体外实验性扫描电子显微镜研究。
Br J Exp Pathol. 1974 Apr;55(2):187-93.
9
Effects of indomethacin on the transcapillary leakage of macromolecules and the efflux of prostaglandins in the paw lymph following experimental scalding injury.吲哚美辛对实验性烫伤后爪部淋巴中大分子物质的跨毛细血管渗漏及前列腺素流出的影响。
Ups J Med Sci. 1973 Jul;78(3):181-8. doi: 10.3109/03009737309178625.
10
Catecholamines: mediator of the hypermetabolic response to thermal injury.儿茶酚胺：热损伤后高代谢反应的介质。
Ann Surg. 1974 Oct;180(4):653-69. doi: 10.1097/00000658-197410000-00031.
Zotero 插件