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红细胞的热损伤。

Thermal damage to red cells.

作者信息

Baar S, Arrowsmith D J

出版信息

J Clin Pathol. 1970 Oct;23(7):572-6. doi: 10.1136/jcp.23.7.572.

DOI:10.1136/jcp.23.7.572
PMID:5483385
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC476838/
Abstract

Erythrocytes from a burned patient show a temporal sequence of morphological changes. Immediate severe changes occur which are followed by a transient phase only of less abnormal morphology. Heating whole blood in vitro to 49 degrees C instead of 50 degrees C does not show the expected dose response curve. Heating whole blood in vitro to 50 degrees C induces progressive morphological changes. Fractionation of whole blood and subsequent heating to 48 degrees C show the older cells to be less deformable.

摘要

烧伤患者的红细胞呈现出形态变化的时间顺序。立即出现严重变化，随后是仅形态异常较轻的短暂阶段。将全血在体外加热至49℃而非50℃未显示出预期的剂量反应曲线。将全血在体外加热至50℃会诱导渐进性形态变化。对全血进行分级分离并随后加热至48℃显示较老的细胞变形性较差。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f7/476838/facaac7100f3/jclinpath00087-0023-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f7/476838/053263eeacb6/jclinpath00087-0021-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f7/476838/d86eccfe0090/jclinpath00087-0021-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f7/476838/1ab3ef4f3d32/jclinpath00087-0022-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f7/476838/706924d9be23/jclinpath00087-0022-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f7/476838/1527e4f010a5/jclinpath00087-0022-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f7/476838/28bc5b52e928/jclinpath00087-0022-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f7/476838/6096c0363819/jclinpath00087-0023-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f7/476838/cd34237357b4/jclinpath00087-0023-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f7/476838/facaac7100f3/jclinpath00087-0023-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f7/476838/053263eeacb6/jclinpath00087-0021-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f7/476838/d86eccfe0090/jclinpath00087-0021-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f7/476838/1ab3ef4f3d32/jclinpath00087-0022-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f7/476838/706924d9be23/jclinpath00087-0022-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f7/476838/1527e4f010a5/jclinpath00087-0022-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f7/476838/28bc5b52e928/jclinpath00087-0022-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f7/476838/6096c0363819/jclinpath00087-0023-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f7/476838/cd34237357b4/jclinpath00087-0023-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f7/476838/facaac7100f3/jclinpath00087-0023-c.jpg

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J Clin Pathol. 1970 Oct;23(7):572-6. doi: 10.1136/jcp.23.7.572.
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本文引用的文献

1
LOCALIZATION OF ERYTHROCYTE MEMBRANE SULFHYDRYL GROUPS ESSENTIAL FOR GLUCOSE TRANSPORT.葡萄糖转运所需红细胞膜巯基的定位
J Gen Physiol. 1965 Mar;48(4):617-32. doi: 10.1085/jgp.48.4.617.
2
THE EFFECT OF HEAT ON HUMAN RED CELL MORPHOLOGY, FRAGILITY, AND SUBSEQUENT SURVIVAL IN VIVO.热对人体红细胞形态、脆性及体内后续存活的影响
J Lab Clin Med. 1964 Dec;64:922-33.
3
DETERMINATION OF DENSITY DISTRIBUTION OF RED CELL POPULATION.红细胞群体密度分布的测定
儿茶酚胺和前列腺素对热损伤红细胞钙外流及滤过性的影响：一项体外研究
Br J Exp Pathol. 1982 Dec;63(6):644-50.
4
Some effects of ultrasound on guinea-pig ear skin.超声对豚鼠耳部皮肤的一些影响。
Br J Ind Med. 1972 Apr;29(2):214-20. doi: 10.1136/oem.29.2.214.
5
Mechanisms of delayed red cell destruction after thermal injury. An experimental in vitro sem study.热损伤后红细胞延迟破坏的机制。一项体外实验性扫描电子显微镜研究。
Br J Exp Pathol. 1974 Apr;55(2):187-93.
6
The mechanism of erythrocyte destruction in the early post-burn period.烧伤后早期红细胞破坏的机制。
Ann Surg. 1973 Dec;178(6):681-6. doi: 10.1097/00000658-197312000-00001.
7
The effect of scald injury upon the distribution of glucose between red cells and plasma and upon the turnover of glucose in red cells in the rat.烫伤对大鼠红细胞与血浆之间葡萄糖分布及红细胞中葡萄糖周转的影响。
Br J Exp Pathol. 1973 Aug;54(4):359-67.
8
Glycolysis of heat damaged red cells in relation to common blood groups.热损伤红细胞的糖酵解与常见血型的关系
Br J Exp Pathol. 1973 Jun;54(3):322-8.
J Lab Clin Med. 1964 Oct;64:668-74.
4
Observations on the alkaline denaturation of haemoglobin in burned rats.烧伤大鼠血红蛋白碱性变性的观察
Br J Exp Pathol. 1962 Apr;43(2):207-12.
5
The disappearance of red cells in patients with burns.烧伤患者红细胞的消失。
Clin Sci. 1956 Feb;15(1):135-48.
6
Surface ultramicroscopy of human blood cells.人体血细胞的表面超微结构
Nature. 1967 Jul 22;215(5099):402-4. doi: 10.1038/215402a0.
7
Experimental studies on the hydration of thermally damaged erythrocytes.热损伤红细胞水合作用的实验研究。
Br J Exp Pathol. 1967 Feb;48(1):130-4.
8
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Am J Physiol. 1966 Jan;210(1):139-45. doi: 10.1152/ajplegacy.1966.210.1.139.
9
Effect on red cells of a small rise in temperature: in vitro studies.温度小幅升高对红细胞的影响：体外研究
Br J Haematol. 1969 Apr;16(4):409-19. doi: 10.1111/j.1365-2141.1969.tb00418.x.
10
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Blood. 1968 Dec;32(6):862-71.