患有桥本甲状腺炎和格雷夫斯病的日本人的HLA - DR抗原
HLA-DR antigens in Japanese with Hashimoto's thyroiditis and Graves' disease.
作者信息
Azuma Y, Sakurami T, Ueno Y, Ohishi M, Saji H, Terasaki P I, Park M S
出版信息
Endocrinol Jpn. 1982 Aug;29(4):423-7. doi: 10.1507/endocrj1954.29.423.
HLA-A, -B, -C and -DR specificities were determined to study the association of HLA in 49 unrelated patients with Hashimoto's thyroiditis and 51 patients with Graves' disease. The results were compared with 144 control subjects from the Japanese population at large. Much less HLA-DR2 was found in the patients with Hashimoto's thyroiditis than in the normal controls. It was present in 16% of the thyroiditis patients compared to 39% in the controls. Also the frequency of HLA-DRl was less in the patients with Graves' disease (0%) than in the controls (15%). No positive association was found for any HLA-antigens in the two diseases.
检测HLA -A、-B、-C和-DR特异性，以研究49例散发性桥本甲状腺炎患者及51例格雷夫斯病患者中HLA的相关性。将结果与来自日本普通人群的144名对照受试者进行比较。发现桥本甲状腺炎患者中HLA -DR2的出现率远低于正常对照。甲状腺炎患者中HLA -DR2出现率为16%，而对照中为39%。格雷夫斯病患者中HLA -DR1的出现率（0%）也低于对照（15%）。在这两种疾病中未发现任何HLA抗原呈阳性相关。
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