Young M R, Henderson S
Immunol Commun. 1982;11(5):345-56. doi: 10.3109/08820138209050734.
C57Bl/6 mice bearing a palpable Lewis lung carcinoma (LLC) were immunized against prostaglandin E2 (PGE2) in order to prevent the immune suppression typical of tumor bearers. Proliferation in response to concanavalin A (Con A) by normal spleen cells cultured in the presence of PGE2 or by spleen cells of LLC-bearing mice cultured with Con A alone was suppressed. However, the mitogenic response of spleen cells from PGE2 immunized LLC-bearing mice was only partially suppressed. The random migration of normal macrophages cultured in the presence of PGE2 or of macrophages from LLC-bearing mice cultured in medium alone was enhanced when compared to the random migration of normal macrophages cultured in the absence of PGE2. In contrast, the random migration of macrophages obtained from PGE2 immunized LLC-bearing mice was the same as that of normal macrophages cultured in the absence of PGE2.
为预防肿瘤携带者典型的免疫抑制，对携带可触及Lewis肺癌（LLC）的C57Bl/6小鼠进行了针对前列腺素E2（PGE2）的免疫。在PGE2存在下培养的正常脾细胞或仅用伴刀豆球蛋白A（Con A）培养的LLC荷瘤小鼠脾细胞对Con A的增殖反应受到抑制。然而，PGE2免疫的LLC荷瘤小鼠脾细胞的促有丝分裂反应仅受到部分抑制。与在无PGE2情况下培养的正常巨噬细胞的随机迁移相比，在PGE2存在下培养的正常巨噬细胞或仅在培养基中培养的LLC荷瘤小鼠巨噬细胞的随机迁移增强。相反，从PGE2免疫的LLC荷瘤小鼠获得的巨噬细胞的随机迁移与在无PGE2情况下培养的正常巨噬细胞相同。
