Young M R, Dizer M
Immunol Commun. 1983;12(1):11-23. doi: 10.3109/08820138309060853.
Mice bearing a Lewis lung carcinoma (LLC) were passively immunized against prostaglandin E2 (PGE2) by administration of rabbit serum containing anti-PGE2 antibodies. The effect of PGE2-immune serum on the suppressed immunity of LLC-bearing mice was examined. Treatment of tumor-bearing mice with anti-PGE2 prevented the suppression of lymphocyte mitogenesis and the alterations in macrophage migration which typically occur in LLC-bearing mice. Furthermore, tumor growth was reduced in LLC-bearing mice which received antibodies directed against PGE2 rather than a placebo treatment.
通过给予含有抗前列腺素E2（PGE2）抗体的兔血清，对携带Lewis肺癌（LLC）的小鼠进行被动免疫以对抗PGE2。研究了PGE2免疫血清对携带LLC小鼠免疫抑制的影响。用抗PGE2治疗荷瘤小鼠可防止淋巴细胞有丝分裂的抑制以及巨噬细胞迁移的改变，而这些改变通常发生在携带LLC的小鼠中。此外，接受针对PGE2抗体而非安慰剂治疗的携带LLC小鼠的肿瘤生长减缓。
