Enhancement of immune function and tumor growth inhibition by antibodies against prostaglandin E2.

Mice bearing a Lewis lung carcinoma (LLC) were passively immunized against prostaglandin E2 (PGE2) by administration of rabbit serum containing anti-PGE2 antibodies. The effect of PGE2-immune serum on the suppressed immunity of LLC-bearing mice was examined. Treatment of tumor-bearing mice with anti-PGE2 prevented the suppression of lymphocyte mitogenesis and the alterations in macrophage migration which typically occur in LLC-bearing mice. Furthermore, tumor growth was reduced in LLC-bearing mice which received antibodies directed against PGE2 rather than a placebo treatment.