Nishimura Y, Yakata H, Kawasaki T, Nakajima T
J Maxillofac Surg. 1982 Nov;10(4):253-8. doi: 10.1016/s0301-0503(82)80050-7.
A review of the Japanese literature revealed 41 well-documented metastatic tumours of the mouth and jaws. The incidence was 1.5 times higher in females than in males and 76% were in the fourth to seventh decades with a mean of 44 years. Instead of the breast which is the most frequently encountered site of origin of metastatic tumours in Caucasians, the uterus followed by the lung, kidney and stomach was the site of primary carcinoma with the highest incidence. Histologically, carcinomas of glandular origin showed the highest rate of metastasis which was followed by choriocarcinomas. Squamous cell carcinoma and sarcoma were unusual. Metastasis occurred in the gingiva in 23 cases and bony involvement was noted in 16 cases. The most common symptoms were swelling, pain, bleeding, paraesthesia and loosening of teeth. The radiographic appearance was quite variable with no specific diagnostic characteristics. The oral lesions were treated by surgery, irradiation or chemotherapy in 32 cases, while no treatment was carried out in seven cases. Prognosis was very poor with 33 fatal cases due to multiple metastases.
对日本文献的回顾显示，有41例记录详实的口腔颌面部转移性肿瘤。女性发病率比男性高1.5倍，76%的患者年龄在40至70岁之间，平均年龄为44岁。与白种人转移性肿瘤最常见的原发部位乳腺不同，子宫是原发癌发病率最高的部位，其次是肺、肾和胃。组织学上，腺源性癌的转移率最高，其次是绒毛膜癌。鳞状细胞癌和肉瘤较少见。23例转移发生在牙龈，16例有骨受累。最常见的症状是肿胀、疼痛、出血、感觉异常和牙齿松动。影像学表现差异很大，无特异性诊断特征。32例口腔病变采用手术、放疗或化疗治疗，7例未进行治疗。由于多处转移，33例患者预后很差，最终死亡。
