Azadeh Payam, Rakhashani Nasser, Yaghobi Joybari Ali, Gorji Bayani Pegah, Sarbaz Samaneh, Farasatinasab Maryam
Dept. of Radiation Oncology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Dept. of Pathology, GILDRC, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
Iran J Pathol. 2016 Fall;11(5):439-442. Epub 2017 Dec 24.
The oral cavity is uncommon site for metastatic disease usually discovered secondary to malignancy. We encountered with a rare case in which metastasis to mandibular bone was the first clinical sign in the diagnosis of breast cancer without any radiographic findings. A 49-yr-old premenopausal woman, was referred to the Department of Medical Oncology of Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran in 2014, presented with pain and tenderness in the left mandibular and temporal bone and paresthesia of the lower left lip and chin. CT scan of mandible showed no significant finding. Four months later, she was referred with complaints left breast pain for 4 wk and worsening swelling, pain and paresthesia. Breast examination revealed a 2 cm firm nodule on the left breast. Based on her medical history and histopathological study, metastatic carcinoma of the breast was suspected. She has received chemoradiotherapy that led to complete relief of her symptoms and remission of the disease. In the presence of an ambiguous sign in oral cavity such as jaw pain or paresthesia, diagnostic examination of malignancy is recommended.
口腔是转移性疾病的罕见部位，通常继发于恶性肿瘤。我们遇到了一例罕见病例，其中下颌骨转移是乳腺癌诊断中的首个临床体征，且无任何影像学表现。一名49岁的绝经前女性，于2014年被转诊至伊朗德黑兰沙希德·贝赫什提医科大学伊玛目侯赛因医院医学肿瘤科，她出现左下颌骨和颞骨疼痛、压痛以及左下唇和下巴感觉异常。下颌骨CT扫描未发现明显异常。四个月后，她因左乳疼痛4周且肿胀、疼痛和感觉异常加重前来就诊。乳房检查发现左乳有一个2厘米的实性结节。根据她的病史和组织病理学研究，怀疑为乳腺转移性癌。她接受了放化疗，症状完全缓解，疾病得到缓解。在口腔出现如颌骨疼痛或感觉异常等不明确体征时，建议对恶性肿瘤进行诊断性检查。
