Forman A, Ulmsten U, Wingerup L, Bányai J
Prostaglandins. 1982 Sep;24(3):303-12. doi: 10.1016/0090-6980(82)90157-5.
In 7 primigravidae admitted for first trimester abortion by dilatation and evacuation, 0.5 mg PGE2 in viscous gel (5 patients) or placebo gel (2 patients) was applied intracervically 6 hours prior to the operation. Throughout the treatment period intrauterine pressure was recorded. Application of placebo gel induced no cervical ripening or myometrial activation. In all patients receiving active gel, a marked improvement of the cervical state was induced by the treatment. In three cases, this priming occurred in parallel to minimal changes in myometrial activity, without regular uterine contractions. In two patients, marked uterine activation was registered due to partly extraamniotic application. It is suggested, that the PGE2-gel has a direct effect on the cervical tissues. Further, the risk of partially applying the gel in the extraamniotic space, thus stimulating the myometrium, depends on the gel volume relative to the dimensions of the cervical canal and the application technique.
在7例因妊娠早期扩张刮宫术而入院的初产妇中，在手术前6小时经宫颈给予0.5毫克前列腺素E2（PGE2）粘性凝胶（5例患者）或安慰剂凝胶（2例患者）。在整个治疗期间记录子宫内压力。应用安慰剂凝胶未引起宫颈成熟或子宫肌层激活。在所有接受活性凝胶的患者中，治疗均引起宫颈状态明显改善。在3例患者中，这种预处理与子宫肌层活动的微小变化同时发生，无规律子宫收缩。在2例患者中，由于部分在羊膜外应用，记录到明显的子宫激活。提示PGE2凝胶对宫颈组织有直接作用。此外，在羊膜外间隙部分应用凝胶从而刺激子宫肌层的风险，取决于凝胶体积与宫颈管尺寸及应用技术的关系。
