Stenberg T
Scand J Dent Res. 1982 Dec;90(6):472-9. doi: 10.1111/j.1600-0722.1982.tb00764.x.
The release of cobalt from a cobalt chromium alloy construction with a major palatal connector (palatal strap) in the maxilla was determined for 10 test subjects. The concentration of cobalt in unstimulated whole saliva and tongue scrapings was estimated 21, 14 and 7 d respectively before and 1, 2, 3, 10, 20 and 30 d after insertion of the cobalt chromium alloy construction. The method used to quantify the cobalt content was flameless atomic absorption spectrophotometry (AAS). The results showed that the median cobalt concentration in saliva and tongue scrapings increased after the insertion of the cobalt chromium alloy construction, with the highest values occurring in the first 2 d after insertion. The tongue scrapings, in general, showed higher cobalt median values than saliva did at all times of estimation. The sampling method described in the present study seems to be useful in long-term investigations in man, where numerous sample collections in the oral cavity are required in order to determine metal content. The risk of negative biologic effects on the human organism caused by the cobalt release from the alloy is discussed.
对10名受试对象测定了上颌带有主要腭部连接体（腭杆）的钴铬合金修复体中钴的释放情况。在插入钴铬合金修复体之前分别于第21、14和7天，以及插入之后第1、2、3、10、20和30天，估算了非刺激性全唾液和舌刮屑中钴的浓度。用于定量钴含量的方法是无火焰原子吸收分光光度法（AAS）。结果显示，插入钴铬合金修复体后，唾液和舌刮屑中的钴浓度中位数增加，最高值出现在插入后的头2天。总体而言，在所有估算时间点，舌刮屑中的钴中位数均高于唾液。本研究中描述的采样方法似乎适用于人体的长期调查，此类调查需要在口腔中进行大量样本采集以确定金属含量。文中讨论了合金释放的钴对人体产生负面生物学效应的风险。
