Gustafsson G, Kreuger A
Acta Paediatr Scand. 1982 Nov;71(6):887-92. doi: 10.1111/j.1651-2227.1982.tb09544.x.
During the six-year period 1975-1980, leukemia was diagnosed in 466 children in Sweden, giving an estimated incidence of 4.4/100 000 children per year (0-15 years at diagnosis). The incidence of acute lymphoblastic leukemia (ALL) was 3.7, of acute nonlymphocytic leukemia (ANLL) 0.6 and of chronic myelocytic leukemia (CML) 0.1/100 000 children per year. The over all incidence among boys was 4.5/100 000 per year and among girls 4.2. The male: female ratio was 1.13. This ratio was 1.22 in ALL and 0.71 in ANLL. Fifty per cent of the children were below 5 years of age at diagnosis, with a pronounced peak between 2-3 years, which was explained by the ALL distribution. In children with acute leukemia 13% had WBC values of greater than 100 X 10(9)/1, 4% had CNS leukemia and 10% had a mediastinal mass at diagnosis. The geographical distribution of leukemia in Sweden was analysed in a search for clusters of cases.
在1975年至1980年的六年期间，瑞典有466名儿童被诊断出患有白血病，估计每年的发病率为每10万名儿童中有4.4例（诊断时年龄在0至15岁）。急性淋巴细胞白血病（ALL）的发病率为3.7例，急性非淋巴细胞白血病（ANLL）为0.6例，慢性粒细胞白血病（CML）为每年每10万名儿童中有0.1例。男孩的总体发病率为每年每10万名中有4.5例，女孩为4.2例。男女比例为1.13。ALL中的这一比例为1.22，ANLL中为0.71。50%的儿童在诊断时年龄低于5岁，在2至3岁之间有一个明显的峰值，这是由ALL的分布情况所解释的。在急性白血病儿童中，13%的白细胞计数（WBC）值大于100×10⁹/L，4%患有中枢神经系统白血病，10%在诊断时有纵隔肿块。对瑞典白血病的地理分布进行了分析，以寻找病例聚集情况。
