Birch J M, Swindell R, Marsden H B, Morris Jones P H
Br J Cancer. 1981 Mar;43(3):324-9. doi: 10.1038/bjc.1981.51.
The annual incidence of leukaemia among children aged up to 14 years as estimated by the Manchester Children's Tumour Registry has been analysed for the 24 years 1954-1977. A significant increase in acute lymphoid leukaemia (ALL) was found, while the incidence of acute myeloid leukaemia (AML) remained constant. Other types of leukaemia were too rare to be analysed separately. The increase in ALL was concentrated among boys in the 1--5-year age group. Analysis with respect to initial white-cell count showed the increase to be more pronounced in children with initial white cell counts of 1-5 x 10(4)/microliters. The proportion of cases presenting in Lancashire compared with Greater Manchester did not change during the study period. The distribution of cases with respect to social class and socio-economic group of the parents also remained constant. Due to advances in the treatment of childhood ALL survival improved considerably during the study period and no increase in mortality was seen.
曼彻斯特儿童肿瘤登记处对1954年至1977年这24年间14岁及以下儿童白血病的年发病率进行了分析。发现急性淋巴细胞白血病（ALL）显著增加，而急性髓细胞白血病（AML）的发病率保持不变。其他类型的白血病过于罕见，无法单独分析。ALL的增加集中在1至5岁年龄组的男孩中。根据初始白细胞计数进行分析表明，初始白细胞计数为1 - 5×10⁴/微升的儿童中增加更为明显。在研究期间，兰开夏郡与大曼彻斯特地区相比病例出现的比例没有变化。病例在父母社会阶层和社会经济群体方面的分布也保持不变。由于儿童ALL治疗方面的进展，在研究期间生存率有了显著提高，且未观察到死亡率增加。
