Svenningsen N W, Lindroth M, Lindquist B
Acta Paediatr Scand Suppl. 1982;296:28-31. doi: 10.1111/j.1651-2227.1982.tb09590.x.
In a prospective longitudinal study of 48 very low birthweight and preterm infants with mean birthweight 1 385 +/- 343 and gestational age 30.8 +/- 2.9 w an assessment was made of the impact of varying the protein intake in the postnatal period from the 3rd to 7th week of life. The infants were randomly allocated to one of three dietary groups with isocaloric energy supply but different protein content--i.e. human milk (1.6 g/100 kcal), formula 1 (2.3 g/100 kcal) and formula 2 (3.0 g/100 kcal). In the human milk group 12 of 18 infants were fed their own mother's breastmilk. During the study period the mean weight gain was slightly higher in the infants fed formula 1 and 2. There were no group differences in S-albumin whereas B-urea-N and B-base deficit were significantly increased in the formula fed infants in comparison to infants fed human milk. After the study period until around 15 weeks of age the slope in weight gain remained slightly higher for formula fed infants. However, the gain in body length and head circumference was equal in all three groups. After around 8 months of age there was no difference in any growth parameter. Neurodevelopmental examinations showed no group differences during the follow-up period to 2 years of age.
在一项针对48名极低出生体重和早产婴儿的前瞻性纵向研究中，这些婴儿的平均出生体重为1385±343克，胎龄为30.8±2.9周，研究评估了出生后第3至7周不同蛋白质摄入量的影响。婴儿被随机分配到三个饮食组之一，能量供应等热量但蛋白质含量不同，即母乳（1.6克/100千卡）、配方奶1（2.3克/100千卡）和配方奶2（3.0克/100千卡）。在母乳组中，18名婴儿中有12名喂养自己母亲的母乳。在研究期间，喂养配方奶1和2的婴儿平均体重增加略高。血清白蛋白无组间差异，而与母乳喂养的婴儿相比，配方奶喂养的婴儿血尿素氮和碱缺乏显著增加。研究期结束后直至约15周龄，配方奶喂养的婴儿体重增加斜率仍略高。然而，三组婴儿的身长和头围增长相同。约8个月龄后，任何生长参数均无差异。神经发育检查显示，在随访至2岁期间无组间差异。
