Singh S K, Dominic C J
Acta Eur Fertil. 1978 Mar;9(1):65-70.
The testis of the musk shrew is resistant to subcutaneous administration of cadmium chloride. In contrast, a single intratesticular injection of cadmium chloride (0.01 to 0.03 mM/kg body weight) caused total destruction of germinal epithelium; Leydig cells, however, regenerated after an initial phase of atrophy. Unilateal injection of the drug induced degenerative changes in the injected testis only; the contralateral testis appeared normal macroscopically and histologically. The factors responsible for the differential response of the testes of this non-scrotal mammal to the two routes of administration of cadmium chloride are discussed.
