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人肠上皮细胞刷状缘的内肽酶活性

Endopeptidase activity of the brush border of human enterocyte.

作者信息

Slabý J, Fric P, Kasafírek E

出版信息

Acta Hepatogastroenterol (Stuttg). 1978 Aug;25(4):295-302.

PMID:696205
Abstract

Succinyl-trialanine-p-nitroanilide (Suc-Ala3-pNA) has been described earlier as a convenient substrate for pancreatic elastase which is not split by trypsin and chymotrypsin. An enzyme activity splitting Suc-Ala3-pNA has been found in the supernatant of the mucous membrane of human small intestine homogenized with Triton X-100.

摘要

琥珀酰-丙氨酰-丙氨酰-对硝基苯胺（Suc-Ala3-pNA）此前已被描述为胰腺弹性蛋白酶的一种便捷底物，它不会被胰蛋白酶和糜蛋白酶分解。在用 Triton X-100 匀浆的人小肠黏膜上清液中发现了一种能分解 Suc-Ala3-pNA 的酶活性。

相似文献

1
Endopeptidase activity of the brush border of human enterocyte.人肠上皮细胞刷状缘的内肽酶活性
Acta Hepatogastroenterol (Stuttg). 1978 Aug;25(4):295-302.
2
Effect of pancreatic proteases on intestinal lactase activity.胰腺蛋白酶对肠道乳糖酶活性的影响。
Gastroenterology. 1980 Nov;79(5 Pt 1):827-32.
3
The responses of rat intestinal brush border and cytosol peptide hydrolase activities to variation in dietary protein content: dietary regulation of intestinal peptide hydrolases.大鼠肠道刷状缘和胞质溶胶肽水解酶活性对膳食蛋白质含量变化的反应：肠道肽水解酶的膳食调节
J Clin Invest. 1974 Oct;54(4):890-8. doi: 10.1172/JCI107828.
4
Zymogram studies of human intestinal brush border and cytoplasmic peptidases.人类肠道刷状缘和细胞质肽酶的酶谱研究。
Gut. 1979 Nov;20(11):987-91. doi: 10.1136/gut.20.11.987.
5
[Endopeptidase activity in the brush border of the human enterocyte (author's transl)].
Cas Lek Cesk. 1978 Mar 31;117(13):385-9.
6
[Proteases of swine small intestine enterocytes. Kinetics of substrate hydrolysis and inhibition of aminopeptidase N from brush border vesicles].[猪小肠肠上皮细胞的蛋白酶。刷状缘小泡中氨肽酶N的底物水解动力学及抑制作用]
Biokhimiia. 1984 Oct;49(10):1733-8.
7
Brush border and cytosol peptidase activities of human small intestine in normal subjects and celiac patients.正常受试者和乳糜泻患者小肠的刷状缘和胞质溶胶肽酶活性
Pediatr Res. 1980 Jun;14(6):812-8. doi: 10.1203/00006450-198006000-00008.
8
The histochemical demonstration of brush border endopeptidase.刷状缘内肽酶的组织化学显示
Histochemistry. 1979 Nov;64(2):205-21. doi: 10.1007/BF00490100.
9
Peptide hydrolases of the human small intestinal mucosa: identification of six distinct enzymes in the brush border membrane.人小肠黏膜的肽水解酶：刷状缘膜中六种不同酶的鉴定。
Clin Chim Acta. 1980 Mar 14;102(1):57-65. doi: 10.1016/0009-8981(80)90433-7.
10
Distribution of brush-border membrane peptidases along the rat intestine.大鼠肠道中刷状缘膜肽酶的分布
Pharm Res. 1994 Jun;11(6):897-900. doi: 10.1023/a:1018946228432.

引用本文的文献

1
In vitro mucosal digestion of synthetic gliadin-derived peptides in celiac disease.
J Protein Chem. 1995 Jul;14(5):335-9. doi: 10.1007/BF01886790.
2
Cleavage of p-nitroanilides of N-acylated tri- and tetrapeptides by alanine endopeptidase from the brush border membranes of rat enterocytes.
Experientia. 1983 Apr 15;39(4):389-90. doi: 10.1007/BF01963140.
3
The histochemical demonstration of brush border endopeptidase.刷状缘内肽酶的组织化学显示
Histochemistry. 1979 Nov;64(2):205-21. doi: 10.1007/BF00490100.