Andreen M, Irestedt L
Acta Anaesthesiol Scand. 1978;22(5):519-26. doi: 10.1111/j.1399-6576.1978.tb01333.x.
Six dogs were subjected to halothane anaesthesia under hypoxic and non-hypoxic conditions. Plasma fluoride levels in hepatic venous and arterial blood, as well as blood flow to the liver, were measured during anaesthesia. The amount of fluoride released by the liver could thus be calculated. Release of fluoride took place in all animals during non-hypoxic halothane anaesthesia. The amount released varied between the individual animals and in three of them it rose further during hypoxic anaesthesia. The occurrence of defluorination of halothane, even under nonhypoxic conditions, may indicate a reductive metabolism in at least some parts of the liver. The significance of this hypothesis is discussed.
六只狗在缺氧和非缺氧条件下接受氟烷麻醉。在麻醉期间测量肝静脉和动脉血中的血浆氟化物水平以及肝脏血流量。由此可以计算出肝脏释放的氟化物量。在非缺氧氟烷麻醉期间，所有动物均发生氟化物释放。释放量在个体动物之间有所不同，其中三只在缺氧麻醉期间进一步上升。即使在非缺氧条件下，氟烷脱氟的发生可能表明肝脏至少某些部位存在还原代谢。讨论了这一假设的意义。
