Rosenbaum K J, Sapthavichaikul S, Skovsted P
Acta Anaesthesiol Scand. 1978;22(5):548-55. doi: 10.1111/j.1399-6576.1978.tb01337.x.
The effect on arterial pressure, EEG, preganglionic sympathetic nervous activity and pulse rate of repeated intravenous administrations of lidocaine (3 mg/kg) was investigated in cats anaesthetized with nitrous oxide. A continuous high voltage, burst-suppression EEG indicating constant seizure activity was found, whereas arterial pressure and sympathetic nervous activity did not change significantly. Although the onset of EEG seizure activity did not change the mean sympathetic activity level, the pattern of firing changed dramatically as every EEG seizure triggered a burst of sympathetic impulses. Barostatic reflexes were active after lidocaine administration unless seizure activity occurred. Thiopental 5 mg/kg given intravenously to cats during continuous lidocaine-induced EEG seizures always abolished the seizure activity without excessive depression of arterial pressure.
在使用氧化亚氮麻醉的猫身上，研究了重复静脉注射利多卡因（3毫克/千克）对动脉血压、脑电图、节前交感神经活动和脉搏率的影响。发现脑电图呈现持续的高电压、爆发抑制，表明存在持续的癫痫活动，而动脉血压和交感神经活动没有显著变化。虽然脑电图癫痫活动的发作并没有改变平均交感神经活动水平，但放电模式发生了显著变化，因为每次脑电图癫痫发作都会引发一阵交感神经冲动。利多卡因给药后，除非发生癫痫活动，压力反射都是活跃的。在利多卡因持续诱导脑电图癫痫发作期间，静脉注射硫喷妥钠5毫克/千克给猫，总能消除癫痫活动，而不会过度降低动脉血压。
