Vasil'ev A V
Arkh Patol. 1982;44(12):41-8.
Investigation of the lungs of 65 children who died of acute leukemia, revealed pathological alterations in 39 of them. Specific leukemic infiltration of the lung parenchyma was found in 29.3%, but it did not play an important role in tanathogenesis. Pneumonias were diagnosed in 46.1% of the observations being the main cause of death in 23%. The inflammatory processes showed a marked tendency for spread because of low immunologic responsiveness of the patients and poor neutrophil reaction. Because of this, segmental pneumonias predominated in our observations, and in 5 cases total bilateral interstitial pneumonias had developed. Three of them were due to Pneumocystis carinii and two were drug pulmonitis.
对65名死于急性白血病的儿童的肺部进行调查发现,其中39名有病理改变。肺实质的特异性白血病浸润见于29.3%的病例,但在致死原因中不起重要作用。46.1%的观察病例诊断为肺炎,其中23%是主要死因。由于患者免疫反应低下和中性粒细胞反应差,炎症过程有明显的扩散倾向。因此,在我们的观察中节段性肺炎占主导,5例发展为双侧全间质肺炎。其中3例由卡氏肺孢子虫引起,2例为药物性肺炎。