皮下和静脉注射后大鼠组织中巴克尔抗叶酸剂（NSC 139105）的比较分布
Comparative distribution of Baker's antifolate (NSC 139105) in rat tissues after subcutaneous and intravenous injections.
作者信息
Yang B C, Ho D H, Brown N S, Benjamin R S, Bodey G P
出版信息
J Med. 1980;11(5-6):413-24.
PMID:6962827
Abstract
The tissue distribution of BAF was compared by intravenous and subcutaneous injections in rats bearing Walker 256 carcinoma. Following a single dose (6 mg/kg containing 30 microCi 4,6-di-14C-BAF), the drug concentrations were determined by radiochemical and dihydrofolate reductase assays. The two methods gave comparable results. No metabolites were found by paper chromatographic separations.
摘要
通过对荷Walker 256癌大鼠进行静脉注射和皮下注射，比较了BAF的组织分布。单次给药（6mg/kg，含30微居里4,6-二-14C-BAF）后，通过放射化学和二氢叶酸还原酶测定法测定药物浓度。两种方法得到了可比的结果。纸色谱分离未发现代谢产物。
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