Nielsen N H, Mikkelsen F, Hansen J P
Acta Pathol Microbiol Scand A. 1978 Mar;86(2):185-93. doi: 10.1111/j.1699-0463.1978.tb02030.x.
Forty-two salivary gland neoplasms were diagnosed in Greenland 1955--1974. Twenty-five cases were malignant of which 92 per cent were an undifferentiated carcinoma, histologically identical to malignant lymphoepithelial lesion. Age adjusted incidence rates for salivary gland carcinomas 1965--1974 were among the highest on record, significantly higher than in Denmark. Prognosis was poor with a 5-year determinate survival rate of 14 per cent. The majority of previously reported malignant lymphoepithelial lesions of salivary glands have occurred in Arctic dwellers in Alaska and Northern Canda. Virus infection and/or dietary deficiencies may be etiological factors. In the present study secondary nasopharyngeal carcinoma could not always be excluded.
1955年至1974年期间，格陵兰岛诊断出42例涎腺肿瘤。其中25例为恶性，92%为未分化癌，组织学上与恶性淋巴上皮病变相同。1965年至1974年涎腺癌的年龄调整发病率是有记录以来最高的，显著高于丹麦。预后较差，5年确定生存率为14%。先前报道的大多数涎腺恶性淋巴上皮病变发生在阿拉斯加和加拿大北部的北极居民中。病毒感染和/或饮食缺乏可能是病因。在本研究中，不能总是排除继发性鼻咽癌。
