Diagn Pathol. 2013 Jul 15;8:115. doi: 10.1186/1746-1596-8-115.
Primary lymphoepithelial-like carcinoma of the parotid gland is a rare tumour with an increased incidence among Eskimos and Orientals. In these populations, it is usually associated with Epstein-Barr virus. In Western countries, salivary gland lymphoepithelial-like carcinomas are uncommon and only 14 cases have been described so far; among these, only five cases showed Epstein-Barr virus positivity.
A 45-year-old woman was admitted to Siena Hospital for evaluation of a pre-existent (2 years) painless and tender submandibular mass, rapidly enlarging since two months. On physical examination, a 2.5-cm mass was found in the right parotid. It was firm, mobile and non-tender. Laboratory data were within reference range. Nuclear magnetic resonance detected a 2,5×1,5×1-cm well-circumscribed mass in the deep lobe of the right parotid. A total right paroditectomy with dissection of a satellite lymph node was performed. On the basis of morphological, immunohistochemical and molecular biology findings, a diagnosis of stage II (according to TNM7) Epstein Barr-virus positive, undifferentiated lymphoepithelial-like carcinoma of the parotid gland was made. Twenty months after surgery the patient was free of disease.
Further studies seem to be necessary to completely elucidate the oncogenic role of Epstein Barr-virus in these tumors, which have identical morphology but different prognosis and variable presence of the virus.
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腮腺原发性淋巴上皮样癌是一种罕见肿瘤，在爱斯基摩人和东方人中发病率较高。在这些人群中，它通常与 Epstein-Barr 病毒有关。在西方国家，涎腺淋巴上皮样癌并不常见，迄今为止仅描述了 14 例；其中，只有 5 例显示 Epstein-Barr 病毒阳性。
一名 45 岁女性因存在（2 年）无痛性和压痛性下颌下肿块而入住锡耶纳医院，肿块自两个月前迅速增大。体格检查发现右侧腮腺有 2.5cm 大小的肿块。肿块坚硬、活动且无触痛。实验室数据在参考范围内。磁共振成像检测到右侧腮腺深叶有一个 2.5×1.5×1cm 界限清楚的肿块。进行了全右侧腮腺切除术和卫星淋巴结解剖。根据形态学、免疫组织化学和分子生物学结果，诊断为 II 期（根据 TNM7）EB 病毒阳性、未分化淋巴上皮样癌。手术后 20 个月，患者无疾病。
似乎需要进一步研究以完全阐明 Epstein-Barr 病毒在这些具有相同形态但预后不同且病毒存在情况不同的肿瘤中的致癌作用。
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