锂诱导的大鼠肾脏局灶性间质纤维化。

Lithium-induced focal interstitial fibrosis in the rat kidney.

作者信息

Hestbech J, Olesen O V, Thomsen K

出版信息

Acta Pathol Microbiol Scand A. 1978 Mar;86(2):195-7. doi: 10.1111/j.1699-0463.1978.tb02031.x.

DOI:10.1111/j.1699-0463.1978.tb02031.x

Abstract

An early stage of focal cortical interstitial fibrosis and nephronic atrophy was found by light microscopy in the kidneys of nine out of twelve rats which had received lithium for 9 weeks. The animals had excessive polyuria and increased requirement for sodium. The histological changes were in their distribution and the morphological structure similar to the lesions recently found in renal biopsy specimens from patients on long-term lithium treatment.

摘要

在接受锂治疗9周的12只大鼠中，有9只大鼠的肾脏经光学显微镜检查发现存在局灶性皮质间质纤维化和肾单位萎缩的早期阶段。这些动物出现多尿过多且对钠的需求量增加。组织学变化在分布和形态结构上与最近在长期接受锂治疗患者的肾活检标本中发现的病变相似。