家猪体内氟化物的药代动力学。

Fluoride pharmacokinetics in the domestic pig.

作者信息

Richards A, Fejerskov O, Ekstrand J

出版信息

J Dent Res. 1982 Sep;61(9):1099-102. doi: 10.1177/00220345820610091401.

DOI:10.1177/00220345820610091401

Abstract

Plasma fluoride concentrations were studied in 11 pigs following single oral or intravenous doses of fluoride. The results showed a less-than-20% bioavailability of fluoride when administered with calcium-rich food. Pharmacokinetic analyses showed that the plasma half-life varied from 0.6 to 1.4 h, depending on diet and route of fluoride administration. These data are comparable to those reported for man, and thus illustrate the suitability of the pig for studies of effects of fluoride on hard tissues.

摘要

对11头猪单次口服或静脉注射氟化物后血浆氟浓度进行了研究。结果表明，与富含钙的食物一起服用时，氟的生物利用度低于20%。药代动力学分析表明，血浆半衰期在0.6至1.4小时之间变化，这取决于饮食和氟化物的给药途径。这些数据与报道的人类数据相当，因此说明了猪适用于氟对硬组织影响的研究。