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[原发性Ⅳ型高脂蛋白血症的临床特征。86例患者分析]

[Clinical characteristics of primary hyperlipoproteinemia type IV. An analysis of 86 patients].

作者信息

Kusić M, Gavrilović M, Mihajlović M, Marković N

出版信息

Zb Vojnomed Akad. 1981;23:15-9.

PMID:6963834
Abstract

In 86 patients with primary HLP type IV over 50% were detected at systematical examinations of non-commissioned officers so that the number of male patients is uncommonly very high, 80, (93%). The highest number of patients--66 (92,5%) belonged to the age group 41-60 years. The analysed group showed the increased incidence of: obesity (60,5%), disturbed glycoregulation (45,3%), arterial hypertension (34,9%), ischemic heart disease (26,7%), hyperuricemia (23%), occlusive peripheral artery disease (16,3%), low values of serum cholesterol concentration LVG (X = 0,98 mmol/l), markedly decreased fibrinolytic activity (eugolobulin fibrinolysis 240 +/- 29 min) and hyperinsulinism (in 9 of 13 patients). Eruptive xanthomas were found in 7 (8,1%) patients. Due to male predominance the incidence of cholelithiasis is lower than expected (8,1%).

摘要

在86例原发性IV型高脂蛋白血症患者中,超过50%是在对士官进行系统检查时发现的,男性患者数量异常之高,达80例(93%)。患者数量最多的是66例(92.5%),年龄在41 - 60岁之间。分析组显示以下疾病发病率增加:肥胖(60.5%)、糖调节紊乱(45.3%)、动脉高血压(34.9%)、缺血性心脏病(26.7%)、高尿酸血症(23%)、闭塞性外周动脉疾病(16.3%)、血清胆固醇浓度低值LVG(X = 0.98 mmol/L)、纤维蛋白溶解活性明显降低(优球蛋白溶解时间240±29分钟)以及高胰岛素血症(13例患者中有9例)。7例(8.1%)患者出现疹性黄瘤。由于男性占主导,胆结石的发病率低于预期(8.1%)。

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