McCoshen J A, Chudasama S, Tyson J E
Placenta Suppl. 1981;3:33-47.
Human amniotic epithelium has been found to consist of two cell types, known as dark and light cells, that are functionally different with respect to the passage of large molecules across the epithelium. Both cell types permit passage of ferritin intercellularly, whereas light cells incorporate this macromolecule. Dark cells impair the passage of 125I-PRL both inter- and intracellularly, whereas it is localized in light cells. In addition to a selectivity regarding the transmembrane passage of large molecules by the two cell types, we suggest that the osmoregulatory action of PRL on human amnion is restricted to the epithelial layer, and that its action may be mediated by light cells.
已发现人羊膜上皮由两种细胞类型组成，即暗细胞和亮细胞，它们在大分子穿过上皮的过程中功能不同。两种细胞类型都允许铁蛋白在细胞间通过，而亮细胞会摄取这种大分子。暗细胞会阻碍125I-PRL在细胞间和细胞内的通过，而它则定位于亮细胞中。除了两种细胞类型对大分子跨膜通过具有选择性外，我们认为PRL对人羊膜的渗透调节作用仅限于上皮层，其作用可能由亮细胞介导。
