恶性胶质瘤的化疗：联合化疗与洛莫司汀治疗效果的比较
Chemotherapy of malignant gliomas: comparison of the effect of polychemo- and CCNU-therapy.
作者信息
Heiss W D
出版信息
Acta Neurochir (Wien). 1978;42(1-2):109-15. doi: 10.1007/BF01406637.
PMID:696439
Abstract
Postoperative survival times of patients suffering from glioblastoma (astrozytoma III-IV) were compared in unselected groups receiving different forms of therapy: standard surgical therapy (16 cases, mean survival time 6.27 +/- 3.75 months), postoperative polychemotherapy (16 patients, survival time 8.96 +/- 4.97 months) or postoperative CCNU-monotherapy (24 cases, survival time 6.98 +/- 4.46 months). The mean survival time in the group receiving polychemotherapy was prolonged significantly when compared to the group with standard treatment. Survival time of the patient group treated with CCNU was not significantly increased. The results indicate that postoperative combination chemotherapy is more effective than CCNU monotherapy.
摘要
对患有胶质母细胞瘤（III-IV级星形细胞瘤）的患者在接受不同治疗方式的未筛选组中比较术后生存时间：标准手术治疗（16例，平均生存时间6.27±3.75个月）、术后多药化疗（16例患者，生存时间8.96±4.97个月）或术后洛莫司汀单药治疗（24例，生存时间6.98±4.46个月）。与标准治疗组相比，接受多药化疗组的平均生存时间显著延长。接受洛莫司汀治疗的患者组生存时间未显著增加。结果表明，术后联合化疗比洛莫司汀单药治疗更有效。
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