[白血病前期状态的细胞遗传学]
[Cytogenetics of preleukemic states].
作者信息
Benítez Ortiz J
出版信息
Rev Esp Oncol. 1982;29(3):445-56.
PMID:6965032
Abstract
In about a half of preleukemic states it is possible to find chromosomal aberrations, as three n. degrees 8 chromosomes, a single n. degrees 7 or n. degrees 5 chromosome, or a partial deletion of long arm or n. degrees 5 chromosomes. From a prognostic point of view, the presence of the indicated chromosomal abnormalities show a three times increased risk to suffer leukemia. Several abnormal cell clones may be produced, but generally only one of them has the proliferative capacity to establish an evolutive non-lymphoblastic acute leukemic process.
摘要
在大约一半的白血病前期状态中，可以发现染色体畸变，如三条8号染色体、一条7号或5号染色体，或5号染色体长臂的部分缺失。从预后的角度来看，上述染色体异常的存在使患白血病的风险增加了两倍。可能会产生几个异常细胞克隆，但通常只有其中一个具有建立一个渐进性非淋巴细胞性急性白血病过程的增殖能力。
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