酒精性肝硬化患者中自体玫瑰花结形成T淋巴细胞减少：与其他T细胞标志物及迟发型皮肤超敏反应无相关性。

Decreased autologous rosette-forming T lymphocytes in alcoholic cirrhosis: absence of correlation with other T cell markers and with delayed cutaneous hypersensitivity.

作者信息

Lang J M, Ruscher H, Hasselmann J P, Grandjean P, Bigel P, Mayer S

出版信息

Int Arch Allergy Appl Immunol. 1980;61(3):337-43. doi: 10.1159/000232456.

Abstract

Autologous rosette-forming T lymphocytes were enumerated in periphal blood of patients with established alcoholic cirrhosis and compared with T lymphocytes forming rosettes with sheep red blood cells (total and 'active' rosette-forming cells; RFC). Decreased autologous RFC was the most frequent T lymphocyte abnormality observed in 43 patients and was shown to occur even in patients with normal total and 'active' RFC. No correlation was found between autologous RFC and total or 'active' RFC. Skin anergy to 2,4-dinitrochlorobenzene was noted in 44% of the patients tested. Autologous RFC did not correlate with delayed cutaneous hypersensitivity to 2,4-dinitrochlorobenzene.

摘要

对确诊为酒精性肝硬化患者的外周血中的自体玫瑰花结形成T淋巴细胞进行计数，并与与绵羊红细胞形成玫瑰花结的T淋巴细胞（总玫瑰花结形成细胞和“活性”玫瑰花结形成细胞；RFC）进行比较。自体RFC降低是在43例患者中观察到的最常见的T淋巴细胞异常，甚至在总RFC和“活性”RFC正常的患者中也有发生。未发现自体RFC与总RFC或“活性”RFC之间存在相关性。在44%的受试患者中发现对2,4-二硝基氯苯皮肤无反应。自体RFC与对2,4-二硝基氯苯的迟发性皮肤超敏反应无关。