Caraux J, Thierry C, Serrou B
J Natl Cancer Inst. 1979 Sep;63(3):593-7. doi: 10.1093/jnci/63.3.593.
The distribution of autologous rosette-forming cells (A-RFC) was determined in 55 samples of peripheral blood mononuclear cells from healthy adult donors and 407 samples from 112 cancer patients. The mean percentage and absolute number of A-RFC were significantly reduced in the cancer patients compared to the healthy adult donors. These values for A-RFC were even more significantly reduced in patients with cancer relapse than in patients with complete remission of cancer. Thus diminution of this pertinent subset of T-lymphocytes has interesting clinical value by its being closely related to an adverse prognosis.
对55份来自健康成年供者的外周血单个核细胞样本以及112例癌症患者的407份样本进行了自体花环形成细胞（A-RFC）分布的测定。与健康成年供者相比，癌症患者中A-RFC的平均百分比和绝对数量显著降低。与癌症完全缓解的患者相比，癌症复发患者的A-RFC值降低得更为显著。因此，这一相关T淋巴细胞亚群的减少因其与不良预后密切相关而具有重要的临床价值。
