Keystone E C, Taylor-Robinson D, Osborn M F, Ling L, Pope C, Fornasier V
Infect Immun. 1980 Jan;27(1):192-6. doi: 10.1128/iai.27.1.192-196.1980.
Mycoplasma pulmonis inoculated parenterally into athymic nude mice congenitally deficient in T cells caused a chronic arthritis of significantly greater magnitude than in immunologically normal mice. During the chronic phase of arthritis, M. pulmonis organisms were isolated from the joints and spleens of athymic nude mice more frequently and in larger numbers than from immunologically normal mice. The results support the concept that impaired T-cell function predisposes the mice to a severe degree of chronic arthritis as a result of their failure to eliminate the causative organisms.
经肠胃外途径接种到先天性缺乏T细胞的无胸腺裸鼠体内的肺支原体，引发了一种慢性关节炎，其严重程度显著高于免疫正常的小鼠。在关节炎的慢性阶段，从无胸腺裸鼠的关节和脾脏中分离出的肺支原体微生物，比从免疫正常的小鼠中分离出的更为频繁，数量也更多。这些结果支持了这样一种观点，即T细胞功能受损使小鼠由于无法清除致病微生物而容易患上严重程度的慢性关节炎。
