Pritchard H, Micklem H S
Clin Exp Immunol. 1973 Aug;14(4):597-607.
The stem cell potential of thymusless mice measured in terms of CFU ratio and the capacity to reprieve lethally irradiated mice was similar to that of /+ and CBA mice. The thymus of →T6T6 rediation chimaeras was repopulated by donor cells. Proliferation of donor cells, presumed to be T-lymphocytes, was observed in regional lymph nodes 3 days after sensitization with oxazolone. T6T6 thymus grafts implanted subcutaneously in mice restored the response to C57BL skin grafts. The mitotic figures in the thymus implant 30 and more days after grafting were almost exclusively of host karyotype. The high proportion of host cells dividing in the lymph nodes of thymus-grafted mice suggested that T-cells derived originally from bone marrow were present. Allogeneic thymus grafts partially restored the response of mice to oxazolone. It is concluded that the failure of thymic development in mice is not due to an absence of thymocyte precursors in the bone marrow or to anything in the general physiological environment which prevents their differentiation to thymocytes and T-lymphocytes. It is presumably the result of defective embryonic development of the epithelial rudiment.
无胸腺小鼠的干细胞潜能，以集落形成单位（CFU）比率及挽救受致死剂量照射小鼠的能力来衡量，与杂合子（/+）和CBA小鼠相似。→T6T6辐射嵌合体的胸腺由供体细胞重新填充。在用恶唑酮致敏3天后，在区域淋巴结中观察到假定为T淋巴细胞的供体细胞增殖。皮下植入小鼠体内的T6T6胸腺移植物恢复了对C57BL皮肤移植物的反应。移植后30天及更长时间，胸腺植入物中的有丝分裂图像几乎完全是宿主核型。在胸腺移植小鼠的淋巴结中，宿主细胞分裂的比例很高，这表明最初源自骨髓的T细胞是存在的。同种异体胸腺移植物部分恢复了小鼠对恶唑酮的反应。结论是，小鼠胸腺发育失败并非由于骨髓中缺乏胸腺细胞前体，也不是由于一般生理环境中任何阻止它们分化为胸腺细胞和T淋巴细胞的因素。这大概是上皮原基胚胎发育缺陷的结果。
