Nakagami Y, Chin H, Tannowa K, Matsumoto K, Kawai H
Invest Urol. 1980 Mar;17(5):386-9.
We evaluated the immunostimulative activity of a Streptococcus pyogenes preparation (OK432) in 50 patients with urogenital carcinoma. Differential lymphocyte blastogenic response to mitogens and quantitation of the lymphocyte subpopulation bearing Fc receptor sites were the two immunoparameters used in this study to assess the status of the cancer-bearing host. Using these immunoparameters, we observed a pattern whereby a substantial deviation from unity in the mitogen reactive ratio and an increase in the number of IgGFcR+T cells were correlated with malignant progression; administration of the immunopotentiator OK432 had a marked effect on immunoparameters reflected by our assays, with a trend toward return to normal values with progression of immunotherapy.
我们评估了化脓性链球菌制剂（OK432）对50例泌尿生殖系统癌患者的免疫刺激活性。对有丝分裂原的淋巴细胞分化增殖反应以及对带有Fc受体位点的淋巴细胞亚群进行定量分析，是本研究中用于评估癌症宿主状态的两个免疫参数。利用这些免疫参数，我们观察到一种模式，即有丝分裂原反应率显著偏离1以及IgGFcR + T细胞数量增加与恶性进展相关；免疫增强剂OK432的给药对我们检测所反映的免疫参数有显著影响，随着免疫治疗的进行有恢复到正常值的趋势。
