Irons R D, Moore B J
Res Commun Chem Pathol Pharmacol. 1980 Jan;27(1):147-55.
Repeated subcutaneous administration of benzene to rabbits (0.25 or 0.5 ml/kg/day) produced a progressive lymphocytopenia with a 80% reduction in total circulating lymphocytes after 10 days of treatment. This decrease in circulating lymphocytes was due primarily to a reduction in B- cells with 17-30% remaining after 10 days of treatment, depending on the dose. Immunoglobin surface receptor - negative cells, presumably T lymphocytes, were relatively unaffected until late in the experiment at the high dose. It is concluded that benzene has a relatively selective cytotoxic effect on circulating B-lymphocytes in the rabbit.
对兔子反复皮下注射苯（0.25或0.5毫升/千克/天），在治疗10天后会导致进行性淋巴细胞减少，循环淋巴细胞总数减少80%。循环淋巴细胞的这种减少主要是由于B细胞减少，治疗10天后，根据剂量不同，剩余17%-30%。免疫球蛋白表面受体阴性细胞，可能是T淋巴细胞，在实验后期高剂量时才受到相对影响。结论是，苯对兔子循环中的B淋巴细胞具有相对选择性的细胞毒性作用。
