Glassman A B, Deas D V, Berlinsky F S, Bennett C E
Ann Clin Lab Sci. 1980 Jan-Feb;10(1):9-12.
Twenty patients with sickle cell disease (14 black females and 6 black males, mean age 31.5 +/- 9.3) were studied by quantitating peripheral T and B lymphocyte percentages and measuring lymphocyte blast transformation (LBT) in response to phytohemagglutinin-P, concanavalin-A and pokeweed mitogen. Compared to normal black controls (19 black females and 1 black male, mean age 32.0 +/- 9.2 years) sickle cell patients had decreased T lymphocytes (50.2 percent +/- 6.2 compare; to 66.2 percent +/- 1.7) and increased B lymphocytes (17.0 percent +/- 3.4 compared to 7.7 percent +/- 1.1). Sickle patients exhibited decreased LBT to all three mitogens.
对20例镰状细胞病患者（14名黑人女性和6名黑人男性，平均年龄31.5±9.3岁）进行了研究，通过定量外周血T和B淋巴细胞百分比，并检测淋巴细胞对植物血凝素-P、刀豆球蛋白-A和商陆有丝分裂原的增殖转化反应（LBT）。与正常黑人对照组（19名黑人女性和1名黑人男性，平均年龄32.0±9.2岁）相比，镰状细胞病患者的T淋巴细胞减少（分别为50.2%±6.2与66.2%±1.7），B淋巴细胞增加（分别为17.0%±3.4与7.7%±1.1）。镰状细胞病患者对所有三种有丝分裂原的LBT均降低。
